The potential of low-cost tests for decision support in neurodegenerative diseases

Mark van Gils, Shadi Mahdiani, Juha Pärkkä, Jyrki Lötjönen

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Abstract

Rationale: There is a great need to detect onset of dementia as early as possible. This can help to provide treatments earlier, which may reduce costs and prolong maintenance of quality of life. For this, we need novel low-cost biomarkers that can be measured during daily living.
Methods: We concentrated on: web-based cognitive testing using the Muistikko test, computer games, and gait analysis. We compared the relationship of these measures with standard neuropsychological assessments used in clinical practice. As there is no efficient composite score for separating healthy, MCI and dementia cases, we developed a global cognitive score (GCS) composed of age, sex, MMSE, and different cognitive tests. Then, regression models were developed to estimate GCS from Muistikko- and computer-game features respectively. For the gait analysis, we studied time- and frequency features from 3D-accelerometry and performed correspondence analysis with established cognitive measures. Over 300 patients from four memory clinics in Europe (Amsterdam, Copenhagen, Kuopio and Perugia) participated in the context of the PredictND EU project.
Results: Both Muistikko test and game-based features show a good correspondence with the GCS. Additionally, gait-extracted features, such as speed, variance and regularity show correlations with different levels of cognitive impairment.
Conclusions: Low-cost measurements, that can be done easily during daily living, contain valuable information related to cognitive impairment. As such, they hold promise to give indications of risk of cognitive decline in early informal settings, thereby enrichening the existing set of tools we have at hand for decision support in dementias.
Original languageEnglish
Title of host publication8th Kuopio Alzheimer Symposium
Subtitle of host publicationFrom translational research to biomarkers, treatment and prevention strategies
EditorsTarja Malm
PublisherUniversity of Eastern Finland
Pages34
Number of pages1
ISBN (Electronic)978-952-61-2822-1
Publication statusPublished - 6 Jun 2018
MoE publication typeNot Eligible
Event8th Kuopio Alzheimer Symposium: From translational research to biomarkers, treatment and prevention strategies - Kuopio, Finland
Duration: 6 Jun 20188 Jun 2018

Conference

Conference8th Kuopio Alzheimer Symposium
CountryFinland
CityKuopio
Period6/06/188/06/18

Fingerprint

Gait
Neurodegenerative Diseases
Dementia
Video Games
Costs and Cost Analysis
Accelerometry
Hand
Biomarkers
Quality of Life
Cognitive Dysfunction
Therapeutics

Keywords

  • dementia; neurdegenerative diseases; low-cost tests; web-based cognitive tests; computer games; gait;

Cite this

van Gils, M., Mahdiani, S., Pärkkä, J., & Lötjönen, J. (2018). The potential of low-cost tests for decision support in neurodegenerative diseases. In T. Malm (Ed.), 8th Kuopio Alzheimer Symposium: From translational research to biomarkers, treatment and prevention strategies (pp. 34). University of Eastern Finland. Reports and Studies in Health Sciences, No. 26
van Gils, Mark ; Mahdiani, Shadi ; Pärkkä, Juha ; Lötjönen, Jyrki. / The potential of low-cost tests for decision support in neurodegenerative diseases. 8th Kuopio Alzheimer Symposium: From translational research to biomarkers, treatment and prevention strategies. editor / Tarja Malm. University of Eastern Finland, 2018. pp. 34 (Reports and Studies in Health Sciences; No. 26).
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van Gils, M, Mahdiani, S, Pärkkä, J & Lötjönen, J 2018, The potential of low-cost tests for decision support in neurodegenerative diseases. in T Malm (ed.), 8th Kuopio Alzheimer Symposium: From translational research to biomarkers, treatment and prevention strategies. University of Eastern Finland, Reports and Studies in Health Sciences, no. 26, pp. 34, 8th Kuopio Alzheimer Symposium, Kuopio, Finland, 6/06/18.

The potential of low-cost tests for decision support in neurodegenerative diseases. / van Gils, Mark; Mahdiani, Shadi; Pärkkä, Juha; Lötjönen, Jyrki.

8th Kuopio Alzheimer Symposium: From translational research to biomarkers, treatment and prevention strategies. ed. / Tarja Malm. University of Eastern Finland, 2018. p. 34 (Reports and Studies in Health Sciences; No. 26).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

TY - CHAP

T1 - The potential of low-cost tests for decision support in neurodegenerative diseases

AU - van Gils, Mark

AU - Mahdiani, Shadi

AU - Pärkkä, Juha

AU - Lötjönen, Jyrki

PY - 2018/6/6

Y1 - 2018/6/6

N2 - Rationale: There is a great need to detect onset of dementia as early as possible. This can help to provide treatments earlier, which may reduce costs and prolong maintenance of quality of life. For this, we need novel low-cost biomarkers that can be measured during daily living.Methods: We concentrated on: web-based cognitive testing using the Muistikko test, computer games, and gait analysis. We compared the relationship of these measures with standard neuropsychological assessments used in clinical practice. As there is no efficient composite score for separating healthy, MCI and dementia cases, we developed a global cognitive score (GCS) composed of age, sex, MMSE, and different cognitive tests. Then, regression models were developed to estimate GCS from Muistikko- and computer-game features respectively. For the gait analysis, we studied time- and frequency features from 3D-accelerometry and performed correspondence analysis with established cognitive measures. Over 300 patients from four memory clinics in Europe (Amsterdam, Copenhagen, Kuopio and Perugia) participated in the context of the PredictND EU project.Results: Both Muistikko test and game-based features show a good correspondence with the GCS. Additionally, gait-extracted features, such as speed, variance and regularity show correlations with different levels of cognitive impairment.Conclusions: Low-cost measurements, that can be done easily during daily living, contain valuable information related to cognitive impairment. As such, they hold promise to give indications of risk of cognitive decline in early informal settings, thereby enrichening the existing set of tools we have at hand for decision support in dementias.

AB - Rationale: There is a great need to detect onset of dementia as early as possible. This can help to provide treatments earlier, which may reduce costs and prolong maintenance of quality of life. For this, we need novel low-cost biomarkers that can be measured during daily living.Methods: We concentrated on: web-based cognitive testing using the Muistikko test, computer games, and gait analysis. We compared the relationship of these measures with standard neuropsychological assessments used in clinical practice. As there is no efficient composite score for separating healthy, MCI and dementia cases, we developed a global cognitive score (GCS) composed of age, sex, MMSE, and different cognitive tests. Then, regression models were developed to estimate GCS from Muistikko- and computer-game features respectively. For the gait analysis, we studied time- and frequency features from 3D-accelerometry and performed correspondence analysis with established cognitive measures. Over 300 patients from four memory clinics in Europe (Amsterdam, Copenhagen, Kuopio and Perugia) participated in the context of the PredictND EU project.Results: Both Muistikko test and game-based features show a good correspondence with the GCS. Additionally, gait-extracted features, such as speed, variance and regularity show correlations with different levels of cognitive impairment.Conclusions: Low-cost measurements, that can be done easily during daily living, contain valuable information related to cognitive impairment. As such, they hold promise to give indications of risk of cognitive decline in early informal settings, thereby enrichening the existing set of tools we have at hand for decision support in dementias.

KW - dementia; neurdegenerative diseases; low-cost tests; web-based cognitive tests; computer games; gait;

M3 - Conference abstract in proceedings

SP - 34

BT - 8th Kuopio Alzheimer Symposium

A2 - Malm, Tarja

PB - University of Eastern Finland

ER -

van Gils M, Mahdiani S, Pärkkä J, Lötjönen J. The potential of low-cost tests for decision support in neurodegenerative diseases. In Malm T, editor, 8th Kuopio Alzheimer Symposium: From translational research to biomarkers, treatment and prevention strategies. University of Eastern Finland. 2018. p. 34. (Reports and Studies in Health Sciences; No. 26).