The temporal relationship between growth hormone and slow wave sleep is weaker after menopause

Nea Kalleinen (Corresponding Author), Arho Virkki, Olli Polo, Sari-Leena Himanen, Kerttu Irjala, Atte Joutsen, Tarja Porkka-Heiskanen, Päivi Polo-Kantola

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Abstract

Objective

To study the temporal association between growth hormone (GH) and slow wave sleep (SWS) in middle-aged women.

Methods

Seventeen premenopausal and 18 postmenopausal women were studied using all-night polygraphic sleep recordings and blood sampling at 20-min intervals. The postmenopausal women were re-studied after six months on hormone therapy (HT) according to a randomized, double-blind, placebo-controlled protocol.

Results

The total sleep time (premenopausal 361.9 ± 81.5 min, postmenopausal 358 ± 67.7 min) and the percentages of the sleep stages did not differ between pre- and postmenopausal women. In postmenopausal women the first GH peak after sleep onset occurred later and with a more variable time interval compared to premenopausal women. The percentage of SWS was highest 40–20 min prior to the first GH peak after sleep onset in both groups with a higher SWS proportion in premenopausal women (p = 0.048), although the total SWS percent for night did not differ. HT did not affect the distribution of SWS in postmenopausal women.

Conclusions

The temporal relationship between GH and SWS in premenopausal women is less robust after menopause and is not improved with HT.

Original languageEnglish
Pages (from-to)96-101
JournalSleep Medicine
Volume13
Issue number1
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

Fingerprint

Menopause
Growth Hormone
Sleep
Hormones
Sleep Stages
Therapeutics
Placebos

Keywords

  • sleep
  • menopause
  • growth hormone
  • slow wave sleep
  • hormone therapy
  • estrogen

Cite this

Kalleinen, N., Virkki, A., Polo, O., Himanen, S-L., Irjala, K., Joutsen, A., ... Polo-Kantola, P. (2012). The temporal relationship between growth hormone and slow wave sleep is weaker after menopause. Sleep Medicine, 13(1), 96-101. https://doi.org/10.1016/j.sleep.2011.05.010
Kalleinen, Nea ; Virkki, Arho ; Polo, Olli ; Himanen, Sari-Leena ; Irjala, Kerttu ; Joutsen, Atte ; Porkka-Heiskanen, Tarja ; Polo-Kantola, Päivi. / The temporal relationship between growth hormone and slow wave sleep is weaker after menopause. In: Sleep Medicine. 2012 ; Vol. 13, No. 1. pp. 96-101.
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title = "The temporal relationship between growth hormone and slow wave sleep is weaker after menopause",
abstract = "ObjectiveTo study the temporal association between growth hormone (GH) and slow wave sleep (SWS) in middle-aged women.MethodsSeventeen premenopausal and 18 postmenopausal women were studied using all-night polygraphic sleep recordings and blood sampling at 20-min intervals. The postmenopausal women were re-studied after six months on hormone therapy (HT) according to a randomized, double-blind, placebo-controlled protocol.ResultsThe total sleep time (premenopausal 361.9 ± 81.5 min, postmenopausal 358 ± 67.7 min) and the percentages of the sleep stages did not differ between pre- and postmenopausal women. In postmenopausal women the first GH peak after sleep onset occurred later and with a more variable time interval compared to premenopausal women. The percentage of SWS was highest 40–20 min prior to the first GH peak after sleep onset in both groups with a higher SWS proportion in premenopausal women (p = 0.048), although the total SWS percent for night did not differ. HT did not affect the distribution of SWS in postmenopausal women.ConclusionsThe temporal relationship between GH and SWS in premenopausal women is less robust after menopause and is not improved with HT.",
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Kalleinen, N, Virkki, A, Polo, O, Himanen, S-L, Irjala, K, Joutsen, A, Porkka-Heiskanen, T & Polo-Kantola, P 2012, 'The temporal relationship between growth hormone and slow wave sleep is weaker after menopause', Sleep Medicine, vol. 13, no. 1, pp. 96-101. https://doi.org/10.1016/j.sleep.2011.05.010

The temporal relationship between growth hormone and slow wave sleep is weaker after menopause. / Kalleinen, Nea (Corresponding Author); Virkki, Arho; Polo, Olli; Himanen, Sari-Leena; Irjala, Kerttu; Joutsen, Atte; Porkka-Heiskanen, Tarja; Polo-Kantola, Päivi.

In: Sleep Medicine, Vol. 13, No. 1, 2012, p. 96-101.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - The temporal relationship between growth hormone and slow wave sleep is weaker after menopause

AU - Kalleinen, Nea

AU - Virkki, Arho

AU - Polo, Olli

AU - Himanen, Sari-Leena

AU - Irjala, Kerttu

AU - Joutsen, Atte

AU - Porkka-Heiskanen, Tarja

AU - Polo-Kantola, Päivi

PY - 2012

Y1 - 2012

N2 - ObjectiveTo study the temporal association between growth hormone (GH) and slow wave sleep (SWS) in middle-aged women.MethodsSeventeen premenopausal and 18 postmenopausal women were studied using all-night polygraphic sleep recordings and blood sampling at 20-min intervals. The postmenopausal women were re-studied after six months on hormone therapy (HT) according to a randomized, double-blind, placebo-controlled protocol.ResultsThe total sleep time (premenopausal 361.9 ± 81.5 min, postmenopausal 358 ± 67.7 min) and the percentages of the sleep stages did not differ between pre- and postmenopausal women. In postmenopausal women the first GH peak after sleep onset occurred later and with a more variable time interval compared to premenopausal women. The percentage of SWS was highest 40–20 min prior to the first GH peak after sleep onset in both groups with a higher SWS proportion in premenopausal women (p = 0.048), although the total SWS percent for night did not differ. HT did not affect the distribution of SWS in postmenopausal women.ConclusionsThe temporal relationship between GH and SWS in premenopausal women is less robust after menopause and is not improved with HT.

AB - ObjectiveTo study the temporal association between growth hormone (GH) and slow wave sleep (SWS) in middle-aged women.MethodsSeventeen premenopausal and 18 postmenopausal women were studied using all-night polygraphic sleep recordings and blood sampling at 20-min intervals. The postmenopausal women were re-studied after six months on hormone therapy (HT) according to a randomized, double-blind, placebo-controlled protocol.ResultsThe total sleep time (premenopausal 361.9 ± 81.5 min, postmenopausal 358 ± 67.7 min) and the percentages of the sleep stages did not differ between pre- and postmenopausal women. In postmenopausal women the first GH peak after sleep onset occurred later and with a more variable time interval compared to premenopausal women. The percentage of SWS was highest 40–20 min prior to the first GH peak after sleep onset in both groups with a higher SWS proportion in premenopausal women (p = 0.048), although the total SWS percent for night did not differ. HT did not affect the distribution of SWS in postmenopausal women.ConclusionsThe temporal relationship between GH and SWS in premenopausal women is less robust after menopause and is not improved with HT.

KW - sleep

KW - menopause

KW - growth hormone

KW - slow wave sleep

KW - hormone therapy

KW - estrogen

U2 - 10.1016/j.sleep.2011.05.010

DO - 10.1016/j.sleep.2011.05.010

M3 - Article

VL - 13

SP - 96

EP - 101

JO - Sleep Medicine

JF - Sleep Medicine

SN - 1389-9457

IS - 1

ER -