The temporal relationship between growth hormone and slow wave sleep is weaker after menopause

Nea Kalleinen (Corresponding Author), Arho Virkki, Olli Polo, Sari-Leena Himanen, Kerttu Irjala, Atte Joutsen, Tarja Porkka-Heiskanen, Päivi Polo-Kantola

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2 Citations (Scopus)

Abstract

Objective

To study the temporal association between growth hormone (GH) and slow wave sleep (SWS) in middle-aged women.

Methods

Seventeen premenopausal and 18 postmenopausal women were studied using all-night polygraphic sleep recordings and blood sampling at 20-min intervals. The postmenopausal women were re-studied after six months on hormone therapy (HT) according to a randomized, double-blind, placebo-controlled protocol.

Results

The total sleep time (premenopausal 361.9 ± 81.5 min, postmenopausal 358 ± 67.7 min) and the percentages of the sleep stages did not differ between pre- and postmenopausal women. In postmenopausal women the first GH peak after sleep onset occurred later and with a more variable time interval compared to premenopausal women. The percentage of SWS was highest 40–20 min prior to the first GH peak after sleep onset in both groups with a higher SWS proportion in premenopausal women (p = 0.048), although the total SWS percent for night did not differ. HT did not affect the distribution of SWS in postmenopausal women.

Conclusions

The temporal relationship between GH and SWS in premenopausal women is less robust after menopause and is not improved with HT.

Original languageEnglish
Pages (from-to)96-101
JournalSleep Medicine
Volume13
Issue number1
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

Keywords

  • sleep
  • menopause
  • growth hormone
  • slow wave sleep
  • hormone therapy
  • estrogen

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  • Cite this

    Kalleinen, N., Virkki, A., Polo, O., Himanen, S-L., Irjala, K., Joutsen, A., Porkka-Heiskanen, T., & Polo-Kantola, P. (2012). The temporal relationship between growth hormone and slow wave sleep is weaker after menopause. Sleep Medicine, 13(1), 96-101. https://doi.org/10.1016/j.sleep.2011.05.010