The temporal relationship between growth hormone and slow wave sleep is weaker after menopause

Nea Kalleinen; Arho Virkki; Olli Polo; Sari-Leena Himanen; Kerttu Irjala; Atte Joutsen; Tarja Porkka-Heiskanen; Päivi Polo-Kantola

doi:10.1016/j.sleep.2011.05.010

The temporal relationship between growth hormone and slow wave sleep is weaker after menopause

Nea Kalleinen (Corresponding Author), Arho Virkki, Olli Polo, Sari-Leena Himanen, Kerttu Irjala, Atte Joutsen, Tarja Porkka-Heiskanen, Päivi Polo-Kantola

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

Objective

To study the temporal association between growth hormone (GH) and slow wave sleep (SWS) in middle-aged women.

Methods

Seventeen premenopausal and 18 postmenopausal women were studied using all-night polygraphic sleep recordings and blood sampling at 20-min intervals. The postmenopausal women were re-studied after six months on hormone therapy (HT) according to a randomized, double-blind, placebo-controlled protocol.

Results

The total sleep time (premenopausal 361.9 ± 81.5 min, postmenopausal 358 ± 67.7 min) and the percentages of the sleep stages did not differ between pre- and postmenopausal women. In postmenopausal women the first GH peak after sleep onset occurred later and with a more variable time interval compared to premenopausal women. The percentage of SWS was highest 40–20 min prior to the first GH peak after sleep onset in both groups with a higher SWS proportion in premenopausal women (p = 0.048), although the total SWS percent for night did not differ. HT did not affect the distribution of SWS in postmenopausal women.

Conclusions

The temporal relationship between GH and SWS in premenopausal women is less robust after menopause and is not improved with HT.

Original language	English
Pages (from-to)	96-101
Journal	Sleep Medicine
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/j.sleep.2011.05.010
Publication status	Published - 2012
MoE publication type	A1 Journal article-refereed

Keywords

sleep
menopause
growth hormone
slow wave sleep
hormone therapy
estrogen

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10.1016/j.sleep.2011.05.010

Cite this

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title = "The temporal relationship between growth hormone and slow wave sleep is weaker after menopause",

abstract = "ObjectiveTo study the temporal association between growth hormone (GH) and slow wave sleep (SWS) in middle-aged women.MethodsSeventeen premenopausal and 18 postmenopausal women were studied using all-night polygraphic sleep recordings and blood sampling at 20-min intervals. The postmenopausal women were re-studied after six months on hormone therapy (HT) according to a randomized, double-blind, placebo-controlled protocol.ResultsThe total sleep time (premenopausal 361.9 ± 81.5 min, postmenopausal 358 ± 67.7 min) and the percentages of the sleep stages did not differ between pre- and postmenopausal women. In postmenopausal women the first GH peak after sleep onset occurred later and with a more variable time interval compared to premenopausal women. The percentage of SWS was highest 40–20 min prior to the first GH peak after sleep onset in both groups with a higher SWS proportion in premenopausal women (p = 0.048), although the total SWS percent for night did not differ. HT did not affect the distribution of SWS in postmenopausal women.ConclusionsThe temporal relationship between GH and SWS in premenopausal women is less robust after menopause and is not improved with HT.",

keywords = "sleep, menopause, growth hormone, slow wave sleep, hormone therapy, estrogen",

author = "Nea Kalleinen and Arho Virkki and Olli Polo and Sari-Leena Himanen and Kerttu Irjala and Atte Joutsen and Tarja Porkka-Heiskanen and P{\"a}ivi Polo-Kantola",

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doi = "10.1016/j.sleep.2011.05.010",

language = "English",

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T1 - The temporal relationship between growth hormone and slow wave sleep is weaker after menopause

AU - Kalleinen, Nea

AU - Virkki, Arho

AU - Polo, Olli

AU - Himanen, Sari-Leena

AU - Irjala, Kerttu

AU - Joutsen, Atte

AU - Porkka-Heiskanen, Tarja

AU - Polo-Kantola, Päivi

PY - 2012

Y1 - 2012

N2 - ObjectiveTo study the temporal association between growth hormone (GH) and slow wave sleep (SWS) in middle-aged women.MethodsSeventeen premenopausal and 18 postmenopausal women were studied using all-night polygraphic sleep recordings and blood sampling at 20-min intervals. The postmenopausal women were re-studied after six months on hormone therapy (HT) according to a randomized, double-blind, placebo-controlled protocol.ResultsThe total sleep time (premenopausal 361.9 ± 81.5 min, postmenopausal 358 ± 67.7 min) and the percentages of the sleep stages did not differ between pre- and postmenopausal women. In postmenopausal women the first GH peak after sleep onset occurred later and with a more variable time interval compared to premenopausal women. The percentage of SWS was highest 40–20 min prior to the first GH peak after sleep onset in both groups with a higher SWS proportion in premenopausal women (p = 0.048), although the total SWS percent for night did not differ. HT did not affect the distribution of SWS in postmenopausal women.ConclusionsThe temporal relationship between GH and SWS in premenopausal women is less robust after menopause and is not improved with HT.

AB - ObjectiveTo study the temporal association between growth hormone (GH) and slow wave sleep (SWS) in middle-aged women.MethodsSeventeen premenopausal and 18 postmenopausal women were studied using all-night polygraphic sleep recordings and blood sampling at 20-min intervals. The postmenopausal women were re-studied after six months on hormone therapy (HT) according to a randomized, double-blind, placebo-controlled protocol.ResultsThe total sleep time (premenopausal 361.9 ± 81.5 min, postmenopausal 358 ± 67.7 min) and the percentages of the sleep stages did not differ between pre- and postmenopausal women. In postmenopausal women the first GH peak after sleep onset occurred later and with a more variable time interval compared to premenopausal women. The percentage of SWS was highest 40–20 min prior to the first GH peak after sleep onset in both groups with a higher SWS proportion in premenopausal women (p = 0.048), although the total SWS percent for night did not differ. HT did not affect the distribution of SWS in postmenopausal women.ConclusionsThe temporal relationship between GH and SWS in premenopausal women is less robust after menopause and is not improved with HT.

KW - sleep

KW - menopause

KW - growth hormone

KW - slow wave sleep

KW - hormone therapy

KW - estrogen

U2 - 10.1016/j.sleep.2011.05.010

DO - 10.1016/j.sleep.2011.05.010

M3 - Article

SN - 1389-9457

VL - 13

SP - 96

EP - 101

JO - Sleep Medicine

JF - Sleep Medicine

IS - 1

ER -

The temporal relationship between growth hormone and slow wave sleep is weaker after menopause

Abstract

Keywords

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