The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer

Donal J. Brennan, Sara Ek, Emma Doyle, Thomas Drew, Michael Foley, Grainne Flannelly, Darran P. O'Connor, William M. Gallagher, Sami Kilpinen, Olli-Pekka Kallioniemi, Karin Jirstrom, Colm O'Herlihy, Carl A. K. Borrebaeck (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Background

Current prognostic molecular markers for epithelial ovarian cancer (EOC) are insufficient. The aim of the current study was to investigate the role of Sox11 in EOC.

Methods

Using an in silico transcriptomic screen, Sox11 was identified as a potential EOC biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC) in 76 EOC cases, which were analysed using automated algorithms to develop a quantitative scoring model.

Results

Sox11 mRNA expression was upregulated in EOC compared to normal tissues. Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in 40% of tumours, who had an improved recurrence-free survival (RFS) (p = 0.002). Multivariate analysis confirmed that Sox11 was an independent predictor of improved RFS after controlling for stage and grade.

Conclusions

These data suggest that Sox11 is a new prognostic marker in EOC. Loss of Sox11 is associated with a decreased RFS and a more aggressive phenotype.

Original languageEnglish
Pages (from-to)1510-1517
JournalEuropean Journal of Cancer
Volume45
Issue number8
DOIs
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

Fingerprint

Transcription Factors
Recurrence
Tumor Biomarkers
Ovarian epithelial cancer
Computer Simulation
Multivariate Analysis
Immunohistochemistry
Phenotype
Messenger RNA
Neoplasms
Proteins

Keywords

  • Sox11
  • Epithelial ovarian cancer
  • Prognosis
  • Automated analysis

Cite this

Brennan, D. J., Ek, S., Doyle, E., Drew, T., Foley, M., Flannelly, G., ... Borrebaeck, C. A. K. (2009). The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer. European Journal of Cancer, 45(8), 1510-1517. https://doi.org/10.1016/j.ejca.2009.01.028
Brennan, Donal J. ; Ek, Sara ; Doyle, Emma ; Drew, Thomas ; Foley, Michael ; Flannelly, Grainne ; O'Connor, Darran P. ; Gallagher, William M. ; Kilpinen, Sami ; Kallioniemi, Olli-Pekka ; Jirstrom, Karin ; O'Herlihy, Colm ; Borrebaeck, Carl A. K. / The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer. In: European Journal of Cancer. 2009 ; Vol. 45, No. 8. pp. 1510-1517.
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title = "The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer",
abstract = "BackgroundCurrent prognostic molecular markers for epithelial ovarian cancer (EOC) are insufficient. The aim of the current study was to investigate the role of Sox11 in EOC.MethodsUsing an in silico transcriptomic screen, Sox11 was identified as a potential EOC biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC) in 76 EOC cases, which were analysed using automated algorithms to develop a quantitative scoring model.ResultsSox11 mRNA expression was upregulated in EOC compared to normal tissues. Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in 40{\%} of tumours, who had an improved recurrence-free survival (RFS) (p = 0.002). Multivariate analysis confirmed that Sox11 was an independent predictor of improved RFS after controlling for stage and grade.ConclusionsThese data suggest that Sox11 is a new prognostic marker in EOC. Loss of Sox11 is associated with a decreased RFS and a more aggressive phenotype.",
keywords = "Sox11, Epithelial ovarian cancer, Prognosis, Automated analysis",
author = "Brennan, {Donal J.} and Sara Ek and Emma Doyle and Thomas Drew and Michael Foley and Grainne Flannelly and O'Connor, {Darran P.} and Gallagher, {William M.} and Sami Kilpinen and Olli-Pekka Kallioniemi and Karin Jirstrom and Colm O'Herlihy and Borrebaeck, {Carl A. K.}",
year = "2009",
doi = "10.1016/j.ejca.2009.01.028",
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pages = "1510--1517",
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Brennan, DJ, Ek, S, Doyle, E, Drew, T, Foley, M, Flannelly, G, O'Connor, DP, Gallagher, WM, Kilpinen, S, Kallioniemi, O-P, Jirstrom, K, O'Herlihy, C & Borrebaeck, CAK 2009, 'The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer', European Journal of Cancer, vol. 45, no. 8, pp. 1510-1517. https://doi.org/10.1016/j.ejca.2009.01.028

The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer. / Brennan, Donal J.; Ek, Sara; Doyle, Emma; Drew, Thomas; Foley, Michael; Flannelly, Grainne; O'Connor, Darran P.; Gallagher, William M.; Kilpinen, Sami; Kallioniemi, Olli-Pekka; Jirstrom, Karin; O'Herlihy, Colm; Borrebaeck, Carl A. K. (Corresponding Author).

In: European Journal of Cancer, Vol. 45, No. 8, 2009, p. 1510-1517.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer

AU - Brennan, Donal J.

AU - Ek, Sara

AU - Doyle, Emma

AU - Drew, Thomas

AU - Foley, Michael

AU - Flannelly, Grainne

AU - O'Connor, Darran P.

AU - Gallagher, William M.

AU - Kilpinen, Sami

AU - Kallioniemi, Olli-Pekka

AU - Jirstrom, Karin

AU - O'Herlihy, Colm

AU - Borrebaeck, Carl A. K.

PY - 2009

Y1 - 2009

N2 - BackgroundCurrent prognostic molecular markers for epithelial ovarian cancer (EOC) are insufficient. The aim of the current study was to investigate the role of Sox11 in EOC.MethodsUsing an in silico transcriptomic screen, Sox11 was identified as a potential EOC biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC) in 76 EOC cases, which were analysed using automated algorithms to develop a quantitative scoring model.ResultsSox11 mRNA expression was upregulated in EOC compared to normal tissues. Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in 40% of tumours, who had an improved recurrence-free survival (RFS) (p = 0.002). Multivariate analysis confirmed that Sox11 was an independent predictor of improved RFS after controlling for stage and grade.ConclusionsThese data suggest that Sox11 is a new prognostic marker in EOC. Loss of Sox11 is associated with a decreased RFS and a more aggressive phenotype.

AB - BackgroundCurrent prognostic molecular markers for epithelial ovarian cancer (EOC) are insufficient. The aim of the current study was to investigate the role of Sox11 in EOC.MethodsUsing an in silico transcriptomic screen, Sox11 was identified as a potential EOC biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC) in 76 EOC cases, which were analysed using automated algorithms to develop a quantitative scoring model.ResultsSox11 mRNA expression was upregulated in EOC compared to normal tissues. Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in 40% of tumours, who had an improved recurrence-free survival (RFS) (p = 0.002). Multivariate analysis confirmed that Sox11 was an independent predictor of improved RFS after controlling for stage and grade.ConclusionsThese data suggest that Sox11 is a new prognostic marker in EOC. Loss of Sox11 is associated with a decreased RFS and a more aggressive phenotype.

KW - Sox11

KW - Epithelial ovarian cancer

KW - Prognosis

KW - Automated analysis

U2 - 10.1016/j.ejca.2009.01.028

DO - 10.1016/j.ejca.2009.01.028

M3 - Article

VL - 45

SP - 1510

EP - 1517

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 8

ER -