@inproceedings{035b45b931e04a7f914813ed27a49ecf,
title = "The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease",
abstract = "Alzheimer's disease, being a major societal burden, demands improvement of current techniques for its treatment and diagnostics. Currently only autopsy histology is able to provide the definite diagnosis for Alzheimer's disease. However, the procedure is rather time consuming and costly. In the current study, we utilized Stokes and Mueller polarimetry techniques to screen for amyloid-β (Aβ) deposits in formalin-fixed, paraffin-embedded mouse brain tissue at different stages of Alzheimer's disease. The study has shown that the presence of Aβ plaques influences the properties of scattered polarized light. The Poincar{\'e} sphere was used as a graphical tool for the visualization of the alterations of the Stokes vector, obtained with Stokes polarimetry, whereas statistical moments were used for the analysis of depolarization distributions that were acquired with Mueller polarimetry. We demonstrate the sensitivity of the last component of the Stokes vector, the degree of polarization and high-order statistical moments of depolarization to the structural alterations in brain tissue, which correspond to the disease progression. The described approach has a potential to improve the existing pathology screening methods and facilitates Aβ detection in AD research.",
keywords = "Alzheimer's, Amyloid-{\ss} plaque, Anisotropy, Depolarization, Scattering, Statistical analysis",
author = "Mariia Borovkova and Alexander Bykov and Alexey Popov and Angelo Pierangelo and Tatiana Novikova and Jens Pahnke and Igor Meglinski",
note = "Funding Information: The work of J.P. was supported by the following grants: Deutsche Forschungsgemeinschaft/ Germany (DFG PA930/12); Wirtschaftsministerium Sachen-Anhalt (EFRE, ZS/2016/05/78617) and the Leibniz Association (Leibniz-Wettbewerb SAW-2015-IPB-2); Latvian Council of Science FLPP/ Latvia (lzp-2018/1-0275); Nasjonalforeningen (16154), HelseS{\O}/ Norway (2016062, 2019054, 2019055); Norsk forskningsr{\aa}det/ Norway (251290 FRIMEDIO, 260786 PROP-AD); Horizon 2020/ European Union (643417 (PROP-AD)). PROP-AD is an EU Joint Programme - Neurodegenerative Disease Research (JPND) project. The project is supported through the following funding organisations under the aegis of JPND - www.jpnd.eu (AKA, no.301228 – Finland , BMBF #01ED1605-Germany, CSO-MOH #30000-12631 - Israel, NFR #260786 - Norway, SRC #2015-06795 - Sweden). This project has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation programme under grant agreement #643417 (JPco-fuND). Funding Information: This project has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation programme under the Marie Sk{\l}odowska-Curie grant agreement No.713606, Cost Actions CA16118, the ATTRACT project funded by the EC under Grant Agreement 777222, Academy of Finland (grants: 314369 and 325097), and INFOTECH strategic funding. Publisher Copyright: {\textcopyright} 2020 SPIE. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.; Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020 ; Conference date: 02-02-2020 Through 05-02-2020",
year = "2020",
month = jan,
day = "1",
doi = "10.1117/12.2550795",
language = "English",
isbn = "978-1-5106-3231-8",
series = "Progress in Biomedical Optics and Imaging",
publisher = "International Society for Optics and Photonics SPIE",
number = "24",
editor = "Alfano, {Robert R.} and Demos, {Stavros G.} and Seddon, {Angela B.}",
booktitle = "Optical Biopsy XVIII",
address = "United States",
}