The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease

Mariia Borovkova (Corresponding author), Alexander Bykov, Alexey Popov, Angelo Pierangelo, Tatiana Novikova, Jens Pahnke, Igor Meglinski

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

Alzheimer's disease, being a major societal burden, demands improvement of current techniques for its treatment and diagnostics. Currently only autopsy histology is able to provide the definite diagnosis for Alzheimer's disease. However, the procedure is rather time consuming and costly. In the current study, we utilized Stokes and Mueller polarimetry techniques to screen for amyloid-β (Aβ) deposits in formalin-fixed, paraffin-embedded mouse brain tissue at different stages of Alzheimer's disease. The study has shown that the presence of Aβ plaques influences the properties of scattered polarized light. The Poincaré sphere was used as a graphical tool for the visualization of the alterations of the Stokes vector, obtained with Stokes polarimetry, whereas statistical moments were used for the analysis of depolarization distributions that were acquired with Mueller polarimetry. We demonstrate the sensitivity of the last component of the Stokes vector, the degree of polarization and high-order statistical moments of depolarization to the structural alterations in brain tissue, which correspond to the disease progression. The described approach has a potential to improve the existing pathology screening methods and facilitates Aβ detection in AD research.

Original languageEnglish
Title of host publicationOptical Biopsy XVIII
Subtitle of host publicationToward Real-Time Spectroscopic Imaging and Diagnosis
EditorsRobert R. Alfano, Stavros G. Demos, Angela B. Seddon
PublisherInternational Society for Optics and Photonics SPIE
ISBN (Electronic)978-151063231-8
DOIs
Publication statusPublished - 1 Jan 2020
MoE publication typeA4 Article in a conference publication
EventOptical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020 - San Francisco, United States
Duration: 2 Feb 20205 Feb 2020

Publication series

SeriesProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11234
ISSN1605-7422

Conference

ConferenceOptical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020
CountryUnited States
CitySan Francisco
Period2/02/205/02/20

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Keywords

  • Alzheimer's
  • Amyloid-ß plaque
  • Anisotropy
  • Depolarization
  • Scattering
  • Statistical analysis

Cite this

Borovkova, M., Bykov, A., Popov, A., Pierangelo, A., Novikova, T., Pahnke, J., & Meglinski, I. (2020). The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease. In R. R. Alfano, S. G. Demos, & A. B. Seddon (Eds.), Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis [112340M] International Society for Optics and Photonics SPIE. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol.. 11234 https://doi.org/10.1117/12.2550795