The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease

Mariia Borovkova; Alexander Bykov; Alexey Popov; Angelo Pierangelo; Tatiana Novikova; Jens Pahnke; Igor Meglinski

doi:10.1117/12.2550795

The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease

Mariia Borovkova^* (Corresponding author), Alexander Bykov, Alexey Popov, Angelo Pierangelo, Tatiana Novikova, Jens Pahnke, Igor Meglinski

^*Corresponding author for this work

Not published at VTT

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

3 Citations (Scopus)

Abstract

Alzheimer's disease, being a major societal burden, demands improvement of current techniques for its treatment and diagnostics. Currently only autopsy histology is able to provide the definite diagnosis for Alzheimer's disease. However, the procedure is rather time consuming and costly. In the current study, we utilized Stokes and Mueller polarimetry techniques to screen for amyloid-β (Aβ) deposits in formalin-fixed, paraffin-embedded mouse brain tissue at different stages of Alzheimer's disease. The study has shown that the presence of Aβ plaques influences the properties of scattered polarized light. The Poincaré sphere was used as a graphical tool for the visualization of the alterations of the Stokes vector, obtained with Stokes polarimetry, whereas statistical moments were used for the analysis of depolarization distributions that were acquired with Mueller polarimetry. We demonstrate the sensitivity of the last component of the Stokes vector, the degree of polarization and high-order statistical moments of depolarization to the structural alterations in brain tissue, which correspond to the disease progression. The described approach has a potential to improve the existing pathology screening methods and facilitates Aβ detection in AD research.

Original language	English
Title of host publication	Optical Biopsy XVIII
Subtitle of host publication	Toward Real-Time Spectroscopic Imaging and Diagnosis
Editors	Robert R. Alfano, Stavros G. Demos, Angela B. Seddon
Publisher	International Society for Optics and Photonics SPIE
ISBN (Electronic)	978-1-5106-3232-5
ISBN (Print)	978-1-5106-3231-8
DOIs	https://doi.org/10.1117/12.2550795
Publication status	Published - 1 Jan 2020
MoE publication type	A4 Article in a conference publication
Event	Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020 - San Francisco, United States Duration: 2 Feb 2020 → 5 Feb 2020

Publication series

Series	Progress in Biomedical Optics and Imaging
Number	24
Volume	21
ISSN	1605-7422

Series	Proceedings of SPIE
Volume	11234
ISSN	0277-786X

Conference

Conference	Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020
Country/Territory	United States
City	San Francisco
Period	2/02/20 → 5/02/20

Keywords

Alzheimer's
Amyloid-ß plaque
Anisotropy
Depolarization
Scattering
Statistical analysis

Access to Document

10.1117/12.2550795

Cite this

Borovkova, M., Bykov, A., Popov, A., Pierangelo, A., Novikova, T., Pahnke, J., & Meglinski, I. (2020). The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease. In R. R. Alfano, S. G. Demos, & A. B. Seddon (Eds.), Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis Article 112340M International Society for Optics and Photonics SPIE. https://doi.org/10.1117/12.2550795

Borovkova, Mariia ; Bykov, Alexander ; Popov, Alexey et al. / The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease. Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis. editor / Robert R. Alfano ; Stavros G. Demos ; Angela B. Seddon. International Society for Optics and Photonics SPIE, 2020. (Progress in Biomedical Optics and Imaging; No. 24, Vol. 21). (Proceedings of SPIE, Vol. 11234).

@inproceedings{035b45b931e04a7f914813ed27a49ecf,

title = "The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease",

abstract = "Alzheimer's disease, being a major societal burden, demands improvement of current techniques for its treatment and diagnostics. Currently only autopsy histology is able to provide the definite diagnosis for Alzheimer's disease. However, the procedure is rather time consuming and costly. In the current study, we utilized Stokes and Mueller polarimetry techniques to screen for amyloid-β (Aβ) deposits in formalin-fixed, paraffin-embedded mouse brain tissue at different stages of Alzheimer's disease. The study has shown that the presence of Aβ plaques influences the properties of scattered polarized light. The Poincar{\'e} sphere was used as a graphical tool for the visualization of the alterations of the Stokes vector, obtained with Stokes polarimetry, whereas statistical moments were used for the analysis of depolarization distributions that were acquired with Mueller polarimetry. We demonstrate the sensitivity of the last component of the Stokes vector, the degree of polarization and high-order statistical moments of depolarization to the structural alterations in brain tissue, which correspond to the disease progression. The described approach has a potential to improve the existing pathology screening methods and facilitates Aβ detection in AD research.",

keywords = "Alzheimer's, Amyloid-{\ss} plaque, Anisotropy, Depolarization, Scattering, Statistical analysis",

author = "Mariia Borovkova and Alexander Bykov and Alexey Popov and Angelo Pierangelo and Tatiana Novikova and Jens Pahnke and Igor Meglinski",

year = "2020",

month = jan,

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doi = "10.1117/12.2550795",

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Borovkova, M, Bykov, A, Popov, A, Pierangelo, A, Novikova, T, Pahnke, J & Meglinski, I 2020, The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease. in RR Alfano, SG Demos & AB Seddon (eds), Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis., 112340M, International Society for Optics and Photonics SPIE, Progress in Biomedical Optics and Imaging, no. 24, vol. 21, Proceedings of SPIE, vol. 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020, San Francisco, California, United States, 2/02/20. https://doi.org/10.1117/12.2550795

The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease. / Borovkova, Mariia (Corresponding author); Bykov, Alexander; Popov, Alexey et al.
Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis. ed. / Robert R. Alfano; Stavros G. Demos; Angela B. Seddon. International Society for Optics and Photonics SPIE, 2020. 112340M (Progress in Biomedical Optics and Imaging; No. 24, Vol. 21). (Proceedings of SPIE, Vol. 11234).

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

TY - GEN

T1 - The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease

AU - Borovkova, Mariia

AU - Bykov, Alexander

AU - Popov, Alexey

AU - Pierangelo, Angelo

AU - Novikova, Tatiana

AU - Pahnke, Jens

AU - Meglinski, Igor

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Alzheimer's disease, being a major societal burden, demands improvement of current techniques for its treatment and diagnostics. Currently only autopsy histology is able to provide the definite diagnosis for Alzheimer's disease. However, the procedure is rather time consuming and costly. In the current study, we utilized Stokes and Mueller polarimetry techniques to screen for amyloid-β (Aβ) deposits in formalin-fixed, paraffin-embedded mouse brain tissue at different stages of Alzheimer's disease. The study has shown that the presence of Aβ plaques influences the properties of scattered polarized light. The Poincaré sphere was used as a graphical tool for the visualization of the alterations of the Stokes vector, obtained with Stokes polarimetry, whereas statistical moments were used for the analysis of depolarization distributions that were acquired with Mueller polarimetry. We demonstrate the sensitivity of the last component of the Stokes vector, the degree of polarization and high-order statistical moments of depolarization to the structural alterations in brain tissue, which correspond to the disease progression. The described approach has a potential to improve the existing pathology screening methods and facilitates Aβ detection in AD research.

AB - Alzheimer's disease, being a major societal burden, demands improvement of current techniques for its treatment and diagnostics. Currently only autopsy histology is able to provide the definite diagnosis for Alzheimer's disease. However, the procedure is rather time consuming and costly. In the current study, we utilized Stokes and Mueller polarimetry techniques to screen for amyloid-β (Aβ) deposits in formalin-fixed, paraffin-embedded mouse brain tissue at different stages of Alzheimer's disease. The study has shown that the presence of Aβ plaques influences the properties of scattered polarized light. The Poincaré sphere was used as a graphical tool for the visualization of the alterations of the Stokes vector, obtained with Stokes polarimetry, whereas statistical moments were used for the analysis of depolarization distributions that were acquired with Mueller polarimetry. We demonstrate the sensitivity of the last component of the Stokes vector, the degree of polarization and high-order statistical moments of depolarization to the structural alterations in brain tissue, which correspond to the disease progression. The described approach has a potential to improve the existing pathology screening methods and facilitates Aβ detection in AD research.

KW - Alzheimer's

KW - Amyloid-ß plaque

KW - Anisotropy

KW - Depolarization

KW - Scattering

KW - Statistical analysis

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U2 - 10.1117/12.2550795

DO - 10.1117/12.2550795

M3 - Conference article in proceedings

AN - SCOPUS:85082704735

SN - 978-1-5106-3231-8

T3 - Progress in Biomedical Optics and Imaging

BT - Optical Biopsy XVIII

A2 - Alfano, Robert R.

A2 - Demos, Stavros G.

A2 - Seddon, Angela B.

PB - International Society for Optics and Photonics SPIE

T2 - Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020

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ER -

Borovkova M, Bykov A, Popov A, Pierangelo A, Novikova T, Pahnke J et al. The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease. In Alfano RR, Demos SG, Seddon AB, editors, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis. International Society for Optics and Photonics SPIE. 2020. 112340M. (Progress in Biomedical Optics and Imaging; No. 24, Vol. 21). (Proceedings of SPIE, Vol. 11234). doi: 10.1117/12.2550795

The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease

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