Boron neutron capture therapy (BNCT) is a radiotherapy
method which utilises an epithermal neutron beam together
with specific 10B compounds accumulating in cancer cells
to treat malignant tumour patients. The ICRU states that
the radiotherapeutic dose to the patient should be
realised within 5% accuracy of the planned dose. The aim
of this study was to 1) develop the dosimetry system for
the FiR 1 BNCT beam, 2) present an estimate of the blood
boron level after a boronphenylalanine (BPA) infusion and
3) develop a patient positioning system for the Finnish
BNCT facility. These individual phases are combined in
the implementation of BNCT treatments at the Finnish BNCT
The physical neutron and gamma doses were determined with
different dosimetrical methods. Different phantom
materials and geometries were used in dose assessments to
provide comprehensive data. Measured and calculated doses
were compared to verify the source model and the
treatment planning system.
The blood boron level influences the boron concentration
in the healthy tissue and in the tumour cells. It is then
essential to predict the blood boron level during the
treatment. A bi-exponential model was created to produce
an estimate of the blood boron level during the
irradiation using the measured blood boron data as
At the Finnish BNCT facility the planned irradiation
fields are carried out with a horizontal static beam
aperture. Thus all the beam directions have to be
realised solely by positioning the patient instead of
moving the beam. A special system was developed to
facilitate the patient positioning in BNCT in which the
positioning techniques used in traditional radiotherapy
cannot be applied.
The methods involved in dosimetry, boron estimation and
positioning all contribute to the reliability of the
eventual patient dose. The methods described here provide
practical means for BNCT and have been established in
studies and actual treatment situations.
 M. Kortesniemi, A. Kosunen et al., Frontiers in
Neutron Capture Therapy (2001) 659.
 P. Ryynänen, M. Kortesniemi et al., Int J Radiat
Oncol. Biol. Phys. (2000) 1145.
 T. Seppälä, M. Kortesniemi et al., Med. & Biol. Eng.
& Comp. (1999) 402.
|Title of host publication||Proceedings of the XXXVI Annual Conference of the Finnish Physical Society|
|Place of Publication||Joensuu|
|Publisher||University of Joensuu|
|Publication status||Published - 2002|
|MoE publication type||Not Eligible|
|Event||XXXVI Annual Conference of the Finnish Physical Society - Joensuu, Finland|
Duration: 13 Mar 2002 → 16 Mar 2002
Conference number: 36
|Series||Selected papers. University of Joensuu, Department of Physics|
|Conference||XXXVI Annual Conference of the Finnish Physical Society|
|Period||13/03/02 → 16/03/02|