Time-resolved Monte Carlo simulation of photon migration in tissue phantom in relation to glucose sensing

A. Popov, A. Priezzhev, Risto Myllylä

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

1 Citation (Scopus)

Abstract

Glucose sensing is of great importance nowadays. In this paper, we apply the Monte Carlo technique to simulate the effect of glucose on pulse propagation within a 4% Intralipid skin phantom. This effect is based on refractive index matching of Intralipid vesicles relative to surrounding liquid (water) if glucose is added. Time-of-flight profiles of femtosecond pulses (906 nm) passed through a 2-mm thick plain glass cuvette are registered by two detectors 0.3 mm in diameter with numerical apertures of 0.19 and 0.29. It is found that glucose levels within the physiological range (100-500 mg/dl) and 1000 mg/dl can be detected due to the effect of glucose on peak location and intensity, and width of the registered pulses.

Original languageEnglish
Title of host publicationICONO 2005
Subtitle of host publicationNonlinear Laser Spectroscopy, High Precision Measurements, and Laser Biomedicine and Chemistry
EditorsSergey N. Bagayev, Andrey Chikishev, Alexander Dmitriev, Martial Ducloy, Tony Heinz, Vladilen Letokhov, Alexander Shkurinov, Hiroaki Takahashi
PublisherInternational Society for Optics and Photonics SPIE
ISBN (Print)978-0-8194-6316-6
DOIs
Publication statusPublished - 15 May 2006
MoE publication typeNot Eligible
EventICONO 2005: Nonlinear Laser Spectroscopy, High Precision Measurements, and Laser Biomedicine and Chemistry - St. Petersburg, Russian Federation
Duration: 11 May 200515 May 2005

Publication series

SeriesProceedings of SPIE
Volume6257
ISSN0277-786X

Conference

ConferenceICONO 2005
CountryRussian Federation
CitySt. Petersburg
Period11/05/0515/05/05

Keywords

  • Glucose
  • Human skin phantom
  • Monte Carlo simulation
  • Photon migration

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    Popov, A., Priezzhev, A., & Myllylä, R. (2006). Time-resolved Monte Carlo simulation of photon migration in tissue phantom in relation to glucose sensing. In S. N. Bagayev, A. Chikishev, A. Dmitriev, M. Ducloy, T. Heinz, V. Letokhov, A. Shkurinov, & H. Takahashi (Eds.), ICONO 2005: Nonlinear Laser Spectroscopy, High Precision Measurements, and Laser Biomedicine and Chemistry [62570Y] International Society for Optics and Photonics SPIE. Proceedings of SPIE, Vol.. 6257 https://doi.org/10.1117/12.678392