Titania nanofibers in gypsum composites: An antibacterial and cytotoxicology study

Melinda Mohl, Aron Dombovari, Elena S. Tuchina, Pavel O. Petrov, Olga A. Bibikova, Ilya Skovorodkin, Alexey P. Popov, Anne Riikka Rautio, Anjana Sarkar, Jyri Pekka Mikkola, Mika Huuhtanen, Seppo Vainio, Riitta L. Keiski, Arthur Prilepsky, Akos Kukovecz, Zoltan Konya, Valery V. Tuchin, Krisztian Kordas

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)

Abstract

Further developments of antibacterial coatings based on photocatalytic nanomaterials could be a promising route towards potential environmentally friendly applications in households, public buildings and health care facilities. Hereby we describe a simple chemical approach to synthesize photocatalytic nanomaterial-embedded coatings using gypsum as a binder. Various types of TiO2 nanofiber-based photocatalytic materials (nitrogen-doped and/or palladium nanoparticle decorated) and their composites with gypsum were characterized by means of scanning (SEM) and transmission (TEM) electron microscopy as well as electron and X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDX) techniques. These gypsum-based composites can be directly applied as commercially available paints on indoor walls. Herein we report that surfaces coated with photocatalytic composites exhibit excellent antimicrobial properties by killing both methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) under blue light. In the case of MSSA cells, the palladium nanoparticle-decorated and nitrogen-doped TiO2 composites demonstrated the highest antimicrobial activity. For the MRSA strain even pure gypsum samples were proven to be efficient in eradicating Gram-positive human pathogens. The cytotoxicity of freestanding TiO2 nanofibers was revealed by analyzing the viability of HeLa cells using MTT and fluorescent cell assays.

Original languageEnglish
Pages (from-to)1307-1316
JournalJournal of Materials Chemistry B
Volume2
Issue number10
DOIs
Publication statusPublished - 14 Mar 2014
MoE publication typeA1 Journal article-refereed

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    Mohl, M., Dombovari, A., Tuchina, E. S., Petrov, P. O., Bibikova, O. A., Skovorodkin, I., Popov, A. P., Rautio, A. R., Sarkar, A., Mikkola, J. P., Huuhtanen, M., Vainio, S., Keiski, R. L., Prilepsky, A., Kukovecz, A., Konya, Z., Tuchin, V. V., & Kordas, K. (2014). Titania nanofibers in gypsum composites: An antibacterial and cytotoxicology study. Journal of Materials Chemistry B, 2(10), 1307-1316. https://doi.org/10.1039/c3tb21644f