Toward an injectable continuous osmotic glucose sensor

Erik Johannessen (Corresponding Author), Olga Krushinitskaya, Andrey Sokolov, Philipp Häfliger, Arno Hoogerwerf, Christian Hinderling, Kari Kautio, Jaakko Lenkkeri, Esko Strömmer, Vasily Kondratyev, Tor Inge Tønnessen, Tom Eirik Mollnes, Henrik Jakobsen, Even Zimmer, Bengt Akselsen

Research output: Contribution to journalArticleScientificpeer-review

25 Citations (Scopus)

Abstract

Background: The growing pandemic of diabetes mellitus places a stringent social and economic burden on the society. A tight glycemic control circumvents the detrimental effects, but the prerogative is the development of new more effective tools capable of longterm tracking of blood glucose (BG) in vivo. Such discontinuous sensor technologies will benefit from an unprecedented marked potential as well as reducing the current life expectancy gap of eight years as part of a therapeutic regime.

Method: A sensor technology based on osmotic pressure incorporates a reversible competitive affinity assay performing glucose-specific recognition. An absolute change in particles generates a pressure that is proportional to the glucose concentration. An integrated pressure transducer and components developed from the silicon micro- and nanofabrication industry translate this pressure into BG data.

Results: An in vitro model based on a 3.6 × 8.7 mm large pill-shaped implant is equipped with a nanoporous membrane holding 4–6 nm large pores. The affinity assay offers a dynamic range of 36–720 mg/dl with a resolution of ±16 mg/dl. An integrated 1 × 1 mm2 large control chip samples the sensor signals for data processing and transmission back to the reader at a total power consumption of 76 µW.

Conclusions: Current studies have demonstrated the design, layout, and performance of a prototype osmotic sensor in vitro using an affinity assay solution for up to four weeks. The small physical size conforms to an injectable device, forming the basis of a conceptual monitor that offers a tight glycemic control of BG.
Original languageEnglish
Pages (from-to)882-892
Number of pages11
JournalJournal of diabetes science and technology
Volume4
Issue number4
DOIs
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

Fingerprint

Glucose sensors
Glucose
Blood Glucose
Assays
Injections
Sensors
Microtechnology
Technology
Pressure Transducers
Pressure
Osmotic Pressure
Pandemics
Silicon
Life Expectancy
Blood
Pressure transducers
Microfabrication
Diabetes Mellitus
Industry
Medical problems

Keywords

  • CGM
  • injectable
  • microtechnology
  • nanotechnology
  • osmotic
  • pressure

Cite this

Johannessen, E., Krushinitskaya, O., Sokolov, A., Häfliger, P., Hoogerwerf, A., Hinderling, C., ... Akselsen, B. (2010). Toward an injectable continuous osmotic glucose sensor. Journal of diabetes science and technology, 4(4), 882-892. https://doi.org/10.1177/193229681000400417
Johannessen, Erik ; Krushinitskaya, Olga ; Sokolov, Andrey ; Häfliger, Philipp ; Hoogerwerf, Arno ; Hinderling, Christian ; Kautio, Kari ; Lenkkeri, Jaakko ; Strömmer, Esko ; Kondratyev, Vasily ; Tønnessen, Tor Inge ; Mollnes, Tom Eirik ; Jakobsen, Henrik ; Zimmer, Even ; Akselsen, Bengt. / Toward an injectable continuous osmotic glucose sensor. In: Journal of diabetes science and technology. 2010 ; Vol. 4, No. 4. pp. 882-892.
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Johannessen, E, Krushinitskaya, O, Sokolov, A, Häfliger, P, Hoogerwerf, A, Hinderling, C, Kautio, K, Lenkkeri, J, Strömmer, E, Kondratyev, V, Tønnessen, TI, Mollnes, TE, Jakobsen, H, Zimmer, E & Akselsen, B 2010, 'Toward an injectable continuous osmotic glucose sensor', Journal of diabetes science and technology, vol. 4, no. 4, pp. 882-892. https://doi.org/10.1177/193229681000400417

Toward an injectable continuous osmotic glucose sensor. / Johannessen, Erik (Corresponding Author); Krushinitskaya, Olga; Sokolov, Andrey; Häfliger, Philipp; Hoogerwerf, Arno; Hinderling, Christian; Kautio, Kari; Lenkkeri, Jaakko; Strömmer, Esko; Kondratyev, Vasily; Tønnessen, Tor Inge; Mollnes, Tom Eirik; Jakobsen, Henrik; Zimmer, Even; Akselsen, Bengt.

In: Journal of diabetes science and technology, Vol. 4, No. 4, 2010, p. 882-892.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Toward an injectable continuous osmotic glucose sensor

AU - Johannessen, Erik

AU - Krushinitskaya, Olga

AU - Sokolov, Andrey

AU - Häfliger, Philipp

AU - Hoogerwerf, Arno

AU - Hinderling, Christian

AU - Kautio, Kari

AU - Lenkkeri, Jaakko

AU - Strömmer, Esko

AU - Kondratyev, Vasily

AU - Tønnessen, Tor Inge

AU - Mollnes, Tom Eirik

AU - Jakobsen, Henrik

AU - Zimmer, Even

AU - Akselsen, Bengt

PY - 2010

Y1 - 2010

N2 - Background: The growing pandemic of diabetes mellitus places a stringent social and economic burden on the society. A tight glycemic control circumvents the detrimental effects, but the prerogative is the development of new more effective tools capable of longterm tracking of blood glucose (BG) in vivo. Such discontinuous sensor technologies will benefit from an unprecedented marked potential as well as reducing the current life expectancy gap of eight years as part of a therapeutic regime.Method: A sensor technology based on osmotic pressure incorporates a reversible competitive affinity assay performing glucose-specific recognition. An absolute change in particles generates a pressure that is proportional to the glucose concentration. An integrated pressure transducer and components developed from the silicon micro- and nanofabrication industry translate this pressure into BG data.Results: An in vitro model based on a 3.6 × 8.7 mm large pill-shaped implant is equipped with a nanoporous membrane holding 4–6 nm large pores. The affinity assay offers a dynamic range of 36–720 mg/dl with a resolution of ±16 mg/dl. An integrated 1 × 1 mm2 large control chip samples the sensor signals for data processing and transmission back to the reader at a total power consumption of 76 µW.Conclusions: Current studies have demonstrated the design, layout, and performance of a prototype osmotic sensor in vitro using an affinity assay solution for up to four weeks. The small physical size conforms to an injectable device, forming the basis of a conceptual monitor that offers a tight glycemic control of BG.

AB - Background: The growing pandemic of diabetes mellitus places a stringent social and economic burden on the society. A tight glycemic control circumvents the detrimental effects, but the prerogative is the development of new more effective tools capable of longterm tracking of blood glucose (BG) in vivo. Such discontinuous sensor technologies will benefit from an unprecedented marked potential as well as reducing the current life expectancy gap of eight years as part of a therapeutic regime.Method: A sensor technology based on osmotic pressure incorporates a reversible competitive affinity assay performing glucose-specific recognition. An absolute change in particles generates a pressure that is proportional to the glucose concentration. An integrated pressure transducer and components developed from the silicon micro- and nanofabrication industry translate this pressure into BG data.Results: An in vitro model based on a 3.6 × 8.7 mm large pill-shaped implant is equipped with a nanoporous membrane holding 4–6 nm large pores. The affinity assay offers a dynamic range of 36–720 mg/dl with a resolution of ±16 mg/dl. An integrated 1 × 1 mm2 large control chip samples the sensor signals for data processing and transmission back to the reader at a total power consumption of 76 µW.Conclusions: Current studies have demonstrated the design, layout, and performance of a prototype osmotic sensor in vitro using an affinity assay solution for up to four weeks. The small physical size conforms to an injectable device, forming the basis of a conceptual monitor that offers a tight glycemic control of BG.

KW - CGM

KW - injectable

KW - microtechnology

KW - nanotechnology

KW - osmotic

KW - pressure

U2 - 10.1177/193229681000400417

DO - 10.1177/193229681000400417

M3 - Article

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JO - Journal of diabetes science and technology

JF - Journal of diabetes science and technology

SN - 1932-2968

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Johannessen E, Krushinitskaya O, Sokolov A, Häfliger P, Hoogerwerf A, Hinderling C et al. Toward an injectable continuous osmotic glucose sensor. Journal of diabetes science and technology. 2010;4(4):882-892. https://doi.org/10.1177/193229681000400417