Towards low-cost biomicrosystems and disposable sensors

Designing and manufacturing of a low-cost sensor platform is a challenging task requiring interdisciplinary approach. Expertise in modeling, sensing methods, materials, optics, photonics, electronics, measurements, microfluidics and microfabrication is needed. The performance of biosensors has been typically unsatisfactory and improvements are still required in various fields: - sensitivity - selectivity - accuracy - precision - stability - reproducibility - reliability - cost - non-specific binding - label free detection - ease of use - biocompatibility. Hybrid integration of biosensors is a solution to these challenges. By combining optics, fluidics, biomaterials (e.g., antibodies) onto single substrate, and together with robust label free measurement technology, a reliable sensor platform can be made. This interdisciplinary approach requires special know-how in many areas: Multi-technological modeling methods to understand the interaction of light with biomaterials and nano-structures; smart and hybrid materials; nanopatterning; advanced photonic devices and micro- and nano-fluidics. Novel mass-manufacturing technologies (i.e. roll-to-roll) are required to keep the sensor cost low. Moreover, functional and technological integration is required when making these sensors.