Towards the development of miniaturized imaging systems for detection of pre-cancer

Michael Descour, Ari Kärkkäinen, Jeremy Rogers, Chen Liang, Bahattin Kilic, Erdogan Madenci, Juha Rantala, Rebecca Richards-Kortum, Eric Anslyn, Russell Dupuis

Research output: Contribution to journalArticleScientificpeer-review

34 Citations (Scopus)

Abstract

In this paper, we describe the progress toward the development of miniaturized imaging systems with applications in medical imaging, and specifically, detection of pre-cancer. The focus of the article is a miniature, optical-sectioning, fluorescence microscope. The miniature microscope is constructed from lithographically printed optics and assembled using a bulk micro-machined silicon microoptical table. Optical elements have been printed in a negative tone hybrid glass to a maximum depth of 59 /spl mu/m and an rms surface roughness between 10-45 nm, fulfilling the requirements of the miniature microscope. Test optical elements have been assembled using silicon-spring equipped mounting slots. The design of silicon springs is presented in this paper. Optical elements can be assembled within the tolerances of an NA=0.4 miniature microscope objective, confirming the concept of simple, zero-alignment assembly.
Original languageEnglish
Pages (from-to)122-130
JournalIEEE Journal of Quantum Electronics
Volume38
Issue number2
DOIs
Publication statusPublished - 2002
MoE publication typeA1 Journal article-refereed

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Imaging systems
Microscopes
Optical devices
cancer
microscopes
Silicon
silicon
Medical imaging
mounting
Mountings
slots
Optics
surface roughness
assembly
Surface roughness
Fluorescence
alignment
optics
Glass
fluorescence

Cite this

Descour, M., Kärkkäinen, A., Rogers, J., Liang, C., Kilic, B., Madenci, E., ... Dupuis, R. (2002). Towards the development of miniaturized imaging systems for detection of pre-cancer. IEEE Journal of Quantum Electronics, 38(2), 122-130. https://doi.org/10.1109/3.980264
Descour, Michael ; Kärkkäinen, Ari ; Rogers, Jeremy ; Liang, Chen ; Kilic, Bahattin ; Madenci, Erdogan ; Rantala, Juha ; Richards-Kortum, Rebecca ; Anslyn, Eric ; Dupuis, Russell. / Towards the development of miniaturized imaging systems for detection of pre-cancer. In: IEEE Journal of Quantum Electronics. 2002 ; Vol. 38, No. 2. pp. 122-130.
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Descour, M, Kärkkäinen, A, Rogers, J, Liang, C, Kilic, B, Madenci, E, Rantala, J, Richards-Kortum, R, Anslyn, E & Dupuis, R 2002, 'Towards the development of miniaturized imaging systems for detection of pre-cancer', IEEE Journal of Quantum Electronics, vol. 38, no. 2, pp. 122-130. https://doi.org/10.1109/3.980264

Towards the development of miniaturized imaging systems for detection of pre-cancer. / Descour, Michael; Kärkkäinen, Ari; Rogers, Jeremy; Liang, Chen; Kilic, Bahattin; Madenci, Erdogan; Rantala, Juha; Richards-Kortum, Rebecca; Anslyn, Eric; Dupuis, Russell.

In: IEEE Journal of Quantum Electronics, Vol. 38, No. 2, 2002, p. 122-130.

Research output: Contribution to journalArticleScientificpeer-review

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