Towards the development of miniaturized imaging systems for detection of pre-cancer

Michael Descour; Ari H.O. Kärkkäinen; Jeremy Rogers; Chen Liang; Bahattin Kilic; Erdogan Madenci; Juha Rantala; Rebecca Richards-Kortum; Eric Anslyn; Russell Dupuis

doi:10.1109/3.980264

Towards the development of miniaturized imaging systems for detection of pre-cancer

Michael Descour, Ari H.O. Kärkkäinen, Jeremy Rogers, Chen Liang, Bahattin Kilic, Erdogan Madenci, Juha Rantala, Rebecca Richards-Kortum, Eric Anslyn, Russell Dupuis

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

42 Citations (Scopus)

Abstract

In this paper, we describe the progress toward the development of miniaturized imaging systems with applications in medical imaging, and specifically, detection of pre-cancer. The focus of the article is a miniature, optical-sectioning, fluorescence microscope. The miniature microscope is constructed from lithographically printed optics and assembled using a bulk micro-machined silicon microoptical table. Optical elements have been printed in a negative tone hybrid glass to a maximum depth of 59 /spl mu/m and an rms surface roughness between 10-45 nm, fulfilling the requirements of the miniature microscope. Test optical elements have been assembled using silicon-spring equipped mounting slots. The design of silicon springs is presented in this paper. Optical elements can be assembled within the tolerances of an NA=0.4 miniature microscope objective, confirming the concept of simple, zero-alignment assembly.

Original language	English
Pages (from-to)	122-130
Journal	IEEE Journal of Quantum Electronics
Volume	38
Issue number	2
DOIs	https://doi.org/10.1109/3.980264
Publication status	Published - 2002
MoE publication type	A1 Journal article-refereed

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abstract = "In this paper, we describe the progress toward the development of miniaturized imaging systems with applications in medical imaging, and specifically, detection of pre-cancer. The focus of the article is a miniature, optical-sectioning, fluorescence microscope. The miniature microscope is constructed from lithographically printed optics and assembled using a bulk micro-machined silicon microoptical table. Optical elements have been printed in a negative tone hybrid glass to a maximum depth of 59 /spl mu/m and an rms surface roughness between 10-45 nm, fulfilling the requirements of the miniature microscope. Test optical elements have been assembled using silicon-spring equipped mounting slots. The design of silicon springs is presented in this paper. Optical elements can be assembled within the tolerances of an NA=0.4 miniature microscope objective, confirming the concept of simple, zero-alignment assembly.",

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AU - Kärkkäinen, Ari H.O.

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AU - Madenci, Erdogan

AU - Rantala, Juha

AU - Richards-Kortum, Rebecca

AU - Anslyn, Eric

AU - Dupuis, Russell

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Towards the development of miniaturized imaging systems for detection of pre-cancer

Abstract

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