Towards the development of miniaturized imaging systems for detection of pre-cancer

Michael Descour, Ari H.O. Kärkkäinen, Jeremy Rogers, Chen Liang, Bahattin Kilic, Erdogan Madenci, Juha Rantala, Rebecca Richards-Kortum, Eric Anslyn, Russell Dupuis

Research output: Contribution to journalArticleScientificpeer-review

42 Citations (Scopus)


In this paper, we describe the progress toward the development of miniaturized imaging systems with applications in medical imaging, and specifically, detection of pre-cancer. The focus of the article is a miniature, optical-sectioning, fluorescence microscope. The miniature microscope is constructed from lithographically printed optics and assembled using a bulk micro-machined silicon microoptical table. Optical elements have been printed in a negative tone hybrid glass to a maximum depth of 59 /spl mu/m and an rms surface roughness between 10-45 nm, fulfilling the requirements of the miniature microscope. Test optical elements have been assembled using silicon-spring equipped mounting slots. The design of silicon springs is presented in this paper. Optical elements can be assembled within the tolerances of an NA=0.4 miniature microscope objective, confirming the concept of simple, zero-alignment assembly.
Original languageEnglish
Pages (from-to)122-130
JournalIEEE Journal of Quantum Electronics
Issue number2
Publication statusPublished - 2002
MoE publication typeA1 Journal article-refereed


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