Abstract
Background: Previous research proposes that transcranial
direct current stimulation (tDCS) could be used to
modulate reward system activity (Chib, 2013).
Consequently, tDCS might affect resting-state neuronal
networks linked to reward circuits. Methods: 1)
Participants: 36 healthy females (20-40 y, right-handed,
naïve to tDCS, no use of tobacco products), were randomly
assigned to receive tDCS or sham stimulation. 2) tDCS
montage: anode between Fp1 and Fp2, cathode over F4
(10-20 EEG system). The stimulation session duration was
20 minutes. The tDCS intensity was 2 mA, and in
the sham group the intensity was 0 mA between fade in and
fade out periods of 15 seconds. 3) Resting-state fMRI was
conducted twice: before ("baseline") and right after the
stimulation (tDCS or sham). Scanning protocol: Philips
Achieva 3.0T TX, FOV 192x192mm2, matrix 64x64, a voxel
size 3x3mm3, TR=2000, TE=27 ms, scanning duration 10 min,
eyes open. The imaging data was processed and analyzed
using SPM12
http://www.fil.ion.ucl.ac.uk/spm/software/spm12/ and
"GIFT" toolbox "Info-max" for Independent component
analysis (ICA)
http://mialab.mrn.org/software/gift/index.html.
ICA was used to isolate resting-state network maps.
Groups were compared according to the simulation
condition (baseline_real to stim_real and baseline_sham
to stim_sham) by paired-sample t-test. Statistical
significance of p<0.05 with FWE and a 10-voxel extent
was required. Default mode network, frontal, left and
right frontoparietal networks were
identified in each subgroup. Results: Increased
functional connectivity (FC) was observed in the tDCS
group in the
right anterior insula, right and left middle frontal
gyrus, right and left superior frontal gyrus and right
middle temporal gyrus, as compared to the sham group.
Conclusions: An increase in FC following tDCS was seen in
right anterior insula and prefrontal cortex. This may
indicate modulation of the reward circuit activity
following tDCS.
Original language | English |
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Publication status | Published - 2016 |
Event | 5th Biennal Concerence on Resting State Brain Connectivity - Vienna, Austria Duration: 21 Sept 2016 → 23 Sept 2016 |
Conference
Conference | 5th Biennal Concerence on Resting State Brain Connectivity |
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Country/Territory | Austria |
City | Vienna |
Period | 21/09/16 → 23/09/16 |