Transcranial direct current stimulation (tDCS) affects resting-state functional connectivity in the reward systems

Liuba Hoffren, Johanna Närväinen, Pekka Kuoppa, Kristiina Juvonen, Timo Liimatainen, Mervi Könönen, Leila Karhunen, Soili Lehto

Research output: Contribution to conferenceConference AbstractScientific

Abstract

Background: Previous research proposes that transcranial direct current stimulation (tDCS) could be used to modulate reward system activity (Chib, 2013). Consequently, tDCS might affect resting-state neuronal networks linked to reward circuits. Methods: 1) Participants: 36 healthy females (20-40 y, right-handed, naïve to tDCS, no use of tobacco products), were randomly assigned to receive tDCS or sham stimulation. 2) tDCS montage: anode between Fp1 and Fp2, cathode over F4 (10-20 EEG system). The stimulation session duration was 20 minutes. The tDCS intensity was 2 mA, and in the sham group the intensity was 0 mA between fade in and fade out periods of 15 seconds. 3) Resting-state fMRI was conducted twice: before ("baseline") and right after the stimulation (tDCS or sham). Scanning protocol: Philips Achieva 3.0T TX, FOV 192x192mm2, matrix 64x64, a voxel size 3x3mm3, TR=2000, TE=27 ms, scanning duration 10 min, eyes open. The imaging data was processed and analyzed using SPM12 http://www.fil.ion.ucl.ac.uk/spm/software/spm12/ and "GIFT" toolbox "Info-max" for Independent component analysis (ICA) http://mialab.mrn.org/software/gift/index.html. ICA was used to isolate resting-state network maps. Groups were compared according to the simulation condition (baseline_real to stim_real and baseline_sham to stim_sham) by paired-sample t-test. Statistical significance of p<0.05 with FWE and a 10-voxel extent was required. Default mode network, frontal, left and right frontoparietal networks were identified in each subgroup. Results: Increased functional connectivity (FC) was observed in the tDCS group in the right anterior insula, right and left middle frontal gyrus, right and left superior frontal gyrus and right middle temporal gyrus, as compared to the sham group. Conclusions: An increase in FC following tDCS was seen in right anterior insula and prefrontal cortex. This may indicate modulation of the reward circuit activity following tDCS.
Original languageEnglish
Publication statusPublished - 2016
Event5th Biennal Concerence on Resting State Brain Connectivity - Vienna, Austria
Duration: 21 Sep 201623 Sep 2016

Conference

Conference5th Biennal Concerence on Resting State Brain Connectivity
CountryAustria
CityVienna
Period21/09/1623/09/16

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Reward
Prefrontal Cortex
Electrodes
Software
Transcranial Direct Current Stimulation
Gift Giving
Temporal Lobe
Tobacco Products
Electroencephalography
Healthy Volunteers
Magnetic Resonance Imaging
Ions

Cite this

Hoffren, L., Närväinen, J., Kuoppa, P., Juvonen, K., Liimatainen, T., Könönen, M., ... Lehto, S. (2016). Transcranial direct current stimulation (tDCS) affects resting-state functional connectivity in the reward systems. Abstract from 5th Biennal Concerence on Resting State Brain Connectivity, Vienna, Austria.
Hoffren, Liuba ; Närväinen, Johanna ; Kuoppa, Pekka ; Juvonen, Kristiina ; Liimatainen, Timo ; Könönen, Mervi ; Karhunen, Leila ; Lehto, Soili. / Transcranial direct current stimulation (tDCS) affects resting-state functional connectivity in the reward systems. Abstract from 5th Biennal Concerence on Resting State Brain Connectivity, Vienna, Austria.
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title = "Transcranial direct current stimulation (tDCS) affects resting-state functional connectivity in the reward systems",
abstract = "Background: Previous research proposes that transcranial direct current stimulation (tDCS) could be used to modulate reward system activity (Chib, 2013). Consequently, tDCS might affect resting-state neuronal networks linked to reward circuits. Methods: 1) Participants: 36 healthy females (20-40 y, right-handed, na{\"i}ve to tDCS, no use of tobacco products), were randomly assigned to receive tDCS or sham stimulation. 2) tDCS montage: anode between Fp1 and Fp2, cathode over F4 (10-20 EEG system). The stimulation session duration was 20 minutes. The tDCS intensity was 2 mA, and in the sham group the intensity was 0 mA between fade in and fade out periods of 15 seconds. 3) Resting-state fMRI was conducted twice: before ({"}baseline{"}) and right after the stimulation (tDCS or sham). Scanning protocol: Philips Achieva 3.0T TX, FOV 192x192mm2, matrix 64x64, a voxel size 3x3mm3, TR=2000, TE=27 ms, scanning duration 10 min, eyes open. The imaging data was processed and analyzed using SPM12 http://www.fil.ion.ucl.ac.uk/spm/software/spm12/ and {"}GIFT{"} toolbox {"}Info-max{"} for Independent component analysis (ICA) http://mialab.mrn.org/software/gift/index.html. ICA was used to isolate resting-state network maps. Groups were compared according to the simulation condition (baseline_real to stim_real and baseline_sham to stim_sham) by paired-sample t-test. Statistical significance of p<0.05 with FWE and a 10-voxel extent was required. Default mode network, frontal, left and right frontoparietal networks were identified in each subgroup. Results: Increased functional connectivity (FC) was observed in the tDCS group in the right anterior insula, right and left middle frontal gyrus, right and left superior frontal gyrus and right middle temporal gyrus, as compared to the sham group. Conclusions: An increase in FC following tDCS was seen in right anterior insula and prefrontal cortex. This may indicate modulation of the reward circuit activity following tDCS.",
author = "Liuba Hoffren and Johanna N{\"a}rv{\"a}inen and Pekka Kuoppa and Kristiina Juvonen and Timo Liimatainen and Mervi K{\"o}n{\"o}nen and Leila Karhunen and Soili Lehto",
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language = "English",
note = "5th Biennal Concerence on Resting State Brain Connectivity ; Conference date: 21-09-2016 Through 23-09-2016",

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Hoffren, L, Närväinen, J, Kuoppa, P, Juvonen, K, Liimatainen, T, Könönen, M, Karhunen, L & Lehto, S 2016, 'Transcranial direct current stimulation (tDCS) affects resting-state functional connectivity in the reward systems' 5th Biennal Concerence on Resting State Brain Connectivity, Vienna, Austria, 21/09/16 - 23/09/16, .

Transcranial direct current stimulation (tDCS) affects resting-state functional connectivity in the reward systems. / Hoffren, Liuba; Närväinen, Johanna; Kuoppa, Pekka; Juvonen, Kristiina; Liimatainen, Timo; Könönen, Mervi; Karhunen, Leila; Lehto, Soili.

2016. Abstract from 5th Biennal Concerence on Resting State Brain Connectivity, Vienna, Austria.

Research output: Contribution to conferenceConference AbstractScientific

TY - CONF

T1 - Transcranial direct current stimulation (tDCS) affects resting-state functional connectivity in the reward systems

AU - Hoffren, Liuba

AU - Närväinen, Johanna

AU - Kuoppa, Pekka

AU - Juvonen, Kristiina

AU - Liimatainen, Timo

AU - Könönen, Mervi

AU - Karhunen, Leila

AU - Lehto, Soili

PY - 2016

Y1 - 2016

N2 - Background: Previous research proposes that transcranial direct current stimulation (tDCS) could be used to modulate reward system activity (Chib, 2013). Consequently, tDCS might affect resting-state neuronal networks linked to reward circuits. Methods: 1) Participants: 36 healthy females (20-40 y, right-handed, naïve to tDCS, no use of tobacco products), were randomly assigned to receive tDCS or sham stimulation. 2) tDCS montage: anode between Fp1 and Fp2, cathode over F4 (10-20 EEG system). The stimulation session duration was 20 minutes. The tDCS intensity was 2 mA, and in the sham group the intensity was 0 mA between fade in and fade out periods of 15 seconds. 3) Resting-state fMRI was conducted twice: before ("baseline") and right after the stimulation (tDCS or sham). Scanning protocol: Philips Achieva 3.0T TX, FOV 192x192mm2, matrix 64x64, a voxel size 3x3mm3, TR=2000, TE=27 ms, scanning duration 10 min, eyes open. The imaging data was processed and analyzed using SPM12 http://www.fil.ion.ucl.ac.uk/spm/software/spm12/ and "GIFT" toolbox "Info-max" for Independent component analysis (ICA) http://mialab.mrn.org/software/gift/index.html. ICA was used to isolate resting-state network maps. Groups were compared according to the simulation condition (baseline_real to stim_real and baseline_sham to stim_sham) by paired-sample t-test. Statistical significance of p<0.05 with FWE and a 10-voxel extent was required. Default mode network, frontal, left and right frontoparietal networks were identified in each subgroup. Results: Increased functional connectivity (FC) was observed in the tDCS group in the right anterior insula, right and left middle frontal gyrus, right and left superior frontal gyrus and right middle temporal gyrus, as compared to the sham group. Conclusions: An increase in FC following tDCS was seen in right anterior insula and prefrontal cortex. This may indicate modulation of the reward circuit activity following tDCS.

AB - Background: Previous research proposes that transcranial direct current stimulation (tDCS) could be used to modulate reward system activity (Chib, 2013). Consequently, tDCS might affect resting-state neuronal networks linked to reward circuits. Methods: 1) Participants: 36 healthy females (20-40 y, right-handed, naïve to tDCS, no use of tobacco products), were randomly assigned to receive tDCS or sham stimulation. 2) tDCS montage: anode between Fp1 and Fp2, cathode over F4 (10-20 EEG system). The stimulation session duration was 20 minutes. The tDCS intensity was 2 mA, and in the sham group the intensity was 0 mA between fade in and fade out periods of 15 seconds. 3) Resting-state fMRI was conducted twice: before ("baseline") and right after the stimulation (tDCS or sham). Scanning protocol: Philips Achieva 3.0T TX, FOV 192x192mm2, matrix 64x64, a voxel size 3x3mm3, TR=2000, TE=27 ms, scanning duration 10 min, eyes open. The imaging data was processed and analyzed using SPM12 http://www.fil.ion.ucl.ac.uk/spm/software/spm12/ and "GIFT" toolbox "Info-max" for Independent component analysis (ICA) http://mialab.mrn.org/software/gift/index.html. ICA was used to isolate resting-state network maps. Groups were compared according to the simulation condition (baseline_real to stim_real and baseline_sham to stim_sham) by paired-sample t-test. Statistical significance of p<0.05 with FWE and a 10-voxel extent was required. Default mode network, frontal, left and right frontoparietal networks were identified in each subgroup. Results: Increased functional connectivity (FC) was observed in the tDCS group in the right anterior insula, right and left middle frontal gyrus, right and left superior frontal gyrus and right middle temporal gyrus, as compared to the sham group. Conclusions: An increase in FC following tDCS was seen in right anterior insula and prefrontal cortex. This may indicate modulation of the reward circuit activity following tDCS.

M3 - Conference Abstract

ER -

Hoffren L, Närväinen J, Kuoppa P, Juvonen K, Liimatainen T, Könönen M et al. Transcranial direct current stimulation (tDCS) affects resting-state functional connectivity in the reward systems. 2016. Abstract from 5th Biennal Concerence on Resting State Brain Connectivity, Vienna, Austria.