Transcriptional analysis of Trichoderma reesei cultivated in the presence of different lignocellulose substrate

Mari Häkkinen (Corresponding author), Markku Saloheimo, Merja Penttilä, Tiina Pakula

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific


    Trichoderma reesei is a soft rot Ascomycete fungus able to secrete enzymes extremely efficiently. Production strains have been traditionally improved
    by classical mutagenesis as well as by specific genetic modifications. The availability of the complete genome sequence of T. reesei has made it possible
    to utilise genome wide analysis methods to study physiology and protein production by the fungus at different conditions and to utilise the information
    obtained to develop new strains with better enzyme production qualities, such as capability for enhanced protein production or production of modified
    enzyme mixtures for degradation of specific types of lignocellulose materials. In this study the hydrolytic system of Trichoderma reesei Rut-C30 in the
    presence of different substrates was studied by cultivating the fungus in the presence of e.g. sophorose, cellulose, pretreated wheat straw, pretreated spruce,
    xylan and bagasse. The cultures were subjected to transcriptional profiling using oligonucleotide microarrays. Differentially expressed genes were
    indentified from the data and expression profiles of glycoside hydrolase genes and other genes encoding lignocellulose degrading enzymes were compared
    in the presence of the different substrates to identify co-regulated groups of genes.
    Original languageEnglish
    Title of host publication26th Fungal Genetics Conference at Asilomar March 15-20, 2011
    PublisherGenetics Society of America
    ChapterPoster Abstracts
    Publication statusPublished - 2011
    Event26th Fungal Genetics Conference - Asilomar, United States
    Duration: 15 Mar 201120 Mar 2011

    Publication series

    SeriesFungal Genetics Reports


    Conference26th Fungal Genetics Conference
    Country/TerritoryUnited States


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