Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism: The GENOBIN study

Ursula Schwab; Tuulikki Seppänen-Laakso; Laxman Yetukuri; Jyrki Ågren; Marjukka Kolehmainen; David E. Laaksonen; Anna-Liisa Ruskeepää; Helena Gylling; Matti Uusitupa; Matej Orešič

doi:10.1371/journal.pone.0002630

Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism: The GENOBIN study

Ursula Schwab (Corresponding Author), Tuulikki Seppänen-Laakso, Laxman Yetukuri, Jyrki Ågren, Marjukka Kolehmainen, David E. Laaksonen, Anna-Liisa Ruskeepää, Helena Gylling, Matti Uusitupa, Matej Orešič (Corresponding Author)

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Abstract

Background

The effect of weight loss on different plasma lipid subclasses at the molecular level is unknown. The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention.

Methodology/Principal Findings

Plasma samples of 9 subjects in the weight reduction group and 10 subjects in the control group were analyzed using mass spectrometry based lipidomic and fatty acid analyses. Body weight decreased in the weight reduction group by 7.8±2.9% (p<0.01). Most of the serum triacylglycerols and phosphatidylcholines were reduced. The decrease in triacylglycerols affected predominantly the saturated short chain fatty acids. This decrease of saturated short chain fatty acid containing triacylglycerols correlated with the increase of insulin sensitivity. However, levels of several longer chain fatty acids, including arachidonic and docosahexanoic acid, were not affected by weight loss. Levels of other lipids known to be associated with obesity such as sphingolipids and lysophosphatidylcholines were not altered by weight reduction.

Conclusions/Significance

Diet-induced weight loss caused significant changes in global lipid profiles in subjects with abnormal glucose metabolism. The observed changes may affect insulin sensitivity and glucose metabolism in these subjects.

Original language	English
Article number	e2630
Number of pages	10
Journal	PLoS ONE
Volume	3
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0002630
Publication status	Published - 2008
MoE publication type	A1 Journal article-refereed

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Schwab, U., Seppänen-Laakso, T., Yetukuri, L., Ågren, J., Kolehmainen, M., Laaksonen, D. E., Ruskeepää, A.-L., Gylling, H., Uusitupa, M., & Orešič, M. (2008). Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism: The GENOBIN study. PLoS ONE, 3(7), Article e2630. https://doi.org/10.1371/journal.pone.0002630

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title = "Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism: The GENOBIN study",

abstract = "BackgroundThe effect of weight loss on different plasma lipid subclasses at the molecular level is unknown. The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention.Methodology/Principal FindingsPlasma samples of 9 subjects in the weight reduction group and 10 subjects in the control group were analyzed using mass spectrometry based lipidomic and fatty acid analyses. Body weight decreased in the weight reduction group by 7.8±2.9% (p<0.01). Most of the serum triacylglycerols and phosphatidylcholines were reduced. The decrease in triacylglycerols affected predominantly the saturated short chain fatty acids. This decrease of saturated short chain fatty acid containing triacylglycerols correlated with the increase of insulin sensitivity. However, levels of several longer chain fatty acids, including arachidonic and docosahexanoic acid, were not affected by weight loss. Levels of other lipids known to be associated with obesity such as sphingolipids and lysophosphatidylcholines were not altered by weight reduction.Conclusions/SignificanceDiet-induced weight loss caused significant changes in global lipid profiles in subjects with abnormal glucose metabolism. The observed changes may affect insulin sensitivity and glucose metabolism in these subjects.",

author = "Ursula Schwab and Tuulikki Sepp{\"a}nen-Laakso and Laxman Yetukuri and Jyrki {\AA}gren and Marjukka Kolehmainen and Laaksonen, {David E.} and Anna-Liisa Ruskeep{\"a}{\"a} and Helena Gylling and Matti Uusitupa and Matej Ore{\v s}i{\v c}",

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doi = "10.1371/journal.pone.0002630",

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journal = "PLoS ONE",

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T1 - Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism

T2 - The GENOBIN study

AU - Schwab, Ursula

AU - Seppänen-Laakso, Tuulikki

AU - Yetukuri, Laxman

AU - Ågren, Jyrki

AU - Kolehmainen, Marjukka

AU - Laaksonen, David E.

AU - Ruskeepää, Anna-Liisa

AU - Gylling, Helena

AU - Uusitupa, Matti

AU - Orešič, Matej

PY - 2008

Y1 - 2008

N2 - BackgroundThe effect of weight loss on different plasma lipid subclasses at the molecular level is unknown. The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention.Methodology/Principal FindingsPlasma samples of 9 subjects in the weight reduction group and 10 subjects in the control group were analyzed using mass spectrometry based lipidomic and fatty acid analyses. Body weight decreased in the weight reduction group by 7.8±2.9% (p<0.01). Most of the serum triacylglycerols and phosphatidylcholines were reduced. The decrease in triacylglycerols affected predominantly the saturated short chain fatty acids. This decrease of saturated short chain fatty acid containing triacylglycerols correlated with the increase of insulin sensitivity. However, levels of several longer chain fatty acids, including arachidonic and docosahexanoic acid, were not affected by weight loss. Levels of other lipids known to be associated with obesity such as sphingolipids and lysophosphatidylcholines were not altered by weight reduction.Conclusions/SignificanceDiet-induced weight loss caused significant changes in global lipid profiles in subjects with abnormal glucose metabolism. The observed changes may affect insulin sensitivity and glucose metabolism in these subjects.

AB - BackgroundThe effect of weight loss on different plasma lipid subclasses at the molecular level is unknown. The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention.Methodology/Principal FindingsPlasma samples of 9 subjects in the weight reduction group and 10 subjects in the control group were analyzed using mass spectrometry based lipidomic and fatty acid analyses. Body weight decreased in the weight reduction group by 7.8±2.9% (p<0.01). Most of the serum triacylglycerols and phosphatidylcholines were reduced. The decrease in triacylglycerols affected predominantly the saturated short chain fatty acids. This decrease of saturated short chain fatty acid containing triacylglycerols correlated with the increase of insulin sensitivity. However, levels of several longer chain fatty acids, including arachidonic and docosahexanoic acid, were not affected by weight loss. Levels of other lipids known to be associated with obesity such as sphingolipids and lysophosphatidylcholines were not altered by weight reduction.Conclusions/SignificanceDiet-induced weight loss caused significant changes in global lipid profiles in subjects with abnormal glucose metabolism. The observed changes may affect insulin sensitivity and glucose metabolism in these subjects.

U2 - 10.1371/journal.pone.0002630

DO - 10.1371/journal.pone.0002630

M3 - Article

SN - 1932-6203

VL - 3

JO - PLoS ONE

JF - PLoS ONE

IS - 7

M1 - e2630

ER -

Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism: The GENOBIN study

Abstract

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