Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism: The GENOBIN study

Ursula Schwab (Corresponding Author), Tuulikki Seppänen-Laakso, Laxman Yetukuri, Jyrki Ågren, Marjukka Kolehmainen, David E. Laaksonen, Anna-Liisa Ruskeepää, Helena Gylling, Matti Uusitupa, Matej Orešič (Corresponding Author)

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Abstract

Background

The effect of weight loss on different plasma lipid subclasses at the molecular level is unknown. The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention.

Methodology/Principal Findings

Plasma samples of 9 subjects in the weight reduction group and 10 subjects in the control group were analyzed using mass spectrometry based lipidomic and fatty acid analyses. Body weight decreased in the weight reduction group by 7.8±2.9% (p<0.01). Most of the serum triacylglycerols and phosphatidylcholines were reduced. The decrease in triacylglycerols affected predominantly the saturated short chain fatty acids. This decrease of saturated short chain fatty acid containing triacylglycerols correlated with the increase of insulin sensitivity. However, levels of several longer chain fatty acids, including arachidonic and docosahexanoic acid, were not affected by weight loss. Levels of other lipids known to be associated with obesity such as sphingolipids and lysophosphatidylcholines were not altered by weight reduction.

Conclusions/Significance

Diet-induced weight loss caused significant changes in global lipid profiles in subjects with abnormal glucose metabolism. The observed changes may affect insulin sensitivity and glucose metabolism in these subjects.

Original languageEnglish
Article numbere2630
Number of pages10
JournalPLoS ONE
Volume3
Issue number7
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

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Schwab, U., Seppänen-Laakso, T., Yetukuri, L., Ågren, J., Kolehmainen, M., Laaksonen, D. E., Ruskeepää, A-L., Gylling, H., Uusitupa, M., & Orešič, M. (2008). Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism: The GENOBIN study. PLoS ONE, 3(7), [e2630]. https://doi.org/10.1371/journal.pone.0002630