Tritium labeling of simple 7-membered ring compounds

Jukka Hiltunen, C. Peng, Z. Yang

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

Seven‐membered ring compounds, from cylcoheptane to complex ring structures containing heteroatoms, substituents and fused phenyl rings, were labeled with tritium, using activated and adsorbed tritium.
The 7‐membered ring structures are generally stable towards reactions with tritium, which allows compounds like 1‐benzosuberone, 1‐aza‐2‐methoxy‐1‐cycloheptene, iminostilbene and clozapine to be labeled to reasonably high specific activities. The best method varies greatly from compound to compound. By optimizing the labeling conditions and use of efficient support exceptionally good results can be obtained.
The Pd‐on‐alumina support gives consistently higher specific activity and less radioimpurity than other supports. Even molecules containing carbon‐halogen bond and hydrogen bound to nitrogen can usually be labeled with tritium at stable positions and without dehalogenation.
Original languageEnglish
Pages (from-to)543-554
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume28
Issue number5
DOIs
Publication statusPublished - 1990
MoE publication typeA1 Journal article-refereed

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Tritium
Labeling
Dehalogenation
Clozapine
Hydrogen
Nitrogen
Molecules

Cite this

Hiltunen, Jukka ; Peng, C. ; Yang, Z. / Tritium labeling of simple 7-membered ring compounds. In: Journal of Labelled Compounds and Radiopharmaceuticals. 1990 ; Vol. 28, No. 5. pp. 543-554.
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Tritium labeling of simple 7-membered ring compounds. / Hiltunen, Jukka; Peng, C.; Yang, Z.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 28, No. 5, 1990, p. 543-554.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Yang, Z.

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AB - Seven‐membered ring compounds, from cylcoheptane to complex ring structures containing heteroatoms, substituents and fused phenyl rings, were labeled with tritium, using activated and adsorbed tritium.The 7‐membered ring structures are generally stable towards reactions with tritium, which allows compounds like 1‐benzosuberone, 1‐aza‐2‐methoxy‐1‐cycloheptene, iminostilbene and clozapine to be labeled to reasonably high specific activities. The best method varies greatly from compound to compound. By optimizing the labeling conditions and use of efficient support exceptionally good results can be obtained. The Pd‐on‐alumina support gives consistently higher specific activity and less radioimpurity than other supports. Even molecules containing carbon‐halogen bond and hydrogen bound to nitrogen can usually be labeled with tritium at stable positions and without dehalogenation.

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