TY - JOUR
T1 - TUBE project
T2 - Transport-derived ultrafines and the brain effects
AU - Martikainen, Maria Viola
AU - Aakko-Saksa, Päivi
AU - Broek, Lenie van den
AU - Cassee, Flemming R.
AU - Carare, Roxana O.
AU - Chew, Sweelin
AU - Dinnyes, Andras
AU - Giugno, Rosalba
AU - Kanninen, Katja M.
AU - Malm, Tarja
AU - Muala, Ala
AU - Nedergaard, Maiken
AU - Oudin, Anna
AU - Oyola, Pedro
AU - Pfeiffer, Tobias V.
AU - Rönkkö, Topi
AU - Saarikoski, Sanna
AU - Sandström, Thomas
AU - Schins, Roel P.F.
AU - Topinka, Jan
AU - Yang, Mo
AU - Zeng, Xiaowen
AU - Westerink, Remco H.S.
AU - Jalava, Pasi I.
N1 - Funding Information:
Funding: This project received funding from the European Union’s Horizon 2020 research and innovation program under Grant Agreement No. 814978 (TUBE).
Funding Information:
To address this unmet need, the Transport-Derived Ultrafines and the Brain Effects (TUBE) project funded by the EU-Horizon 2020 brings together interdisciplinary expertise that aims to unravel fundamental questions of traffic-related air pollutants and the health of the brain (Figure 1). The main objective of the TUBE project is to generate critical information for the risk assessment of traffic-related UFPs and their implication in the pathogenesis of AD. TUBE research seeks to reveal new biomarkers of UFP exposure effects on brain health and the development of AD and leverages on new in vitro human-cell-based models and in mice. Employing state-of-the-art research methodologies, TUBE intends to:
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/12/28
Y1 - 2021/12/28
N2 - The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linked with neurological diseases, exacerbated cognitive dysfunction, and Alzheimer’s disease. However, the exact air pollutant compositions and exposure scenarios leading to these adverse health effects are not known. Although several components of air pollution may be at play, recent experimental studies point to a key role of ultrafine particles (UFPs). While the importance of UFPs has been recognized, almost nothing is known about the smallest fraction of UFPs, and only >23 nm emissions are regulated in the EU. Moreover, the role of the semivolatile fraction of the emissions has been neglected. The Transport-Derived Ultrafines and the Brain Effects (TUBE) project will increase knowledge on harmful ultrafine air pollutants, as well as semivolatile compounds related to adverse health effects. By including all the major current combustion and emission control technologies, the TUBE project aims to provide new information on the adverse health effects of current traffic, as well as information for decision makers to develop more effective emission legislation. Most importantly, the TUBE project will include adverse health effects beyond the respiratory system; TUBE will assess how air pollution affects the brain and how air pollution particles might be removed from the brain. The purpose of this report is to describe the TUBE project, its background, and its goals.
AB - The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linked with neurological diseases, exacerbated cognitive dysfunction, and Alzheimer’s disease. However, the exact air pollutant compositions and exposure scenarios leading to these adverse health effects are not known. Although several components of air pollution may be at play, recent experimental studies point to a key role of ultrafine particles (UFPs). While the importance of UFPs has been recognized, almost nothing is known about the smallest fraction of UFPs, and only >23 nm emissions are regulated in the EU. Moreover, the role of the semivolatile fraction of the emissions has been neglected. The Transport-Derived Ultrafines and the Brain Effects (TUBE) project will increase knowledge on harmful ultrafine air pollutants, as well as semivolatile compounds related to adverse health effects. By including all the major current combustion and emission control technologies, the TUBE project aims to provide new information on the adverse health effects of current traffic, as well as information for decision makers to develop more effective emission legislation. Most importantly, the TUBE project will include adverse health effects beyond the respiratory system; TUBE will assess how air pollution affects the brain and how air pollution particles might be removed from the brain. The purpose of this report is to describe the TUBE project, its background, and its goals.
KW - Air pollution
KW - Brain
KW - CNS
KW - Particulate matter
KW - Toxicology
KW - Traffic
KW - UFP
UR - http://www.scopus.com/inward/record.url?scp=85121690427&partnerID=8YFLogxK
U2 - 10.3390/ijerph19010311
DO - 10.3390/ijerph19010311
M3 - Article
C2 - 35010571
AN - SCOPUS:85121690427
VL - 19
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 1
M1 - 311
ER -
