Twisted α-keto amides as transition-state analogues for acyl-transfer reactions: Synthesis of the immunoconjugates

Jari Yli-Kauhaluoma, Kim Janda (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Abstract

Two new haptens were employed as antigens to elicit antibodies for acyl-transfer reactions. The haptens, both α-keto amides were designed to elicit antibodies which could twist potential substrates into a much more reactive conformation. The rationale for their design, synthesis, and immunization protocols will be discussed.

Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.
Original languageEnglish
Pages (from-to)521-528
Number of pages8
JournalBioorganic & Medicinal Chemistry
Volume2
Issue number6
DOIs
Publication statusPublished - 1994
MoE publication typeA1 Journal article-refereed

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