Abstract
Two new haptens were employed as antigens to elicit antibodies for acyl-transfer reactions. The haptens, both α-keto amides were designed to elicit antibodies which could twist potential substrates into a much more reactive conformation. The rationale for their design, synthesis, and immunization protocols will be discussed.
Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.
Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 521-528 |
| Number of pages | 8 |
| Journal | Bioorganic & Medicinal Chemistry |
| Volume | 2 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1994 |
| MoE publication type | A1 Journal article-refereed |
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Yli-Kauhaluoma, J., & Janda, K. (1994). Twisted α-keto amides as transition-state analogues for acyl-transfer reactions: Synthesis of the immunoconjugates. Bioorganic & Medicinal Chemistry, 2(6), 521-528. https://doi.org/10.1016/0968-0896(94)80022-7