Twisted α-keto amides as transition-state analogues for acyl-transfer reactions: Synthesis of the immunoconjugates

Jari Yli-Kauhaluoma, Kim Janda (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Abstract

Two new haptens were employed as antigens to elicit antibodies for acyl-transfer reactions. The haptens, both α-keto amides were designed to elicit antibodies which could twist potential substrates into a much more reactive conformation. The rationale for their design, synthesis, and immunization protocols will be discussed.

Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.
Original languageEnglish
Pages (from-to)521-528
Number of pages8
JournalBioorganic & Medicinal Chemistry
Volume2
Issue number6
DOIs
Publication statusPublished - 1994
MoE publication typeA1 Journal article-refereed

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Immunoconjugates
Amides
Immunization
Haptens
Antibodies
Antigens
Conformations
Substrates

Cite this

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title = "Twisted α-keto amides as transition-state analogues for acyl-transfer reactions: Synthesis of the immunoconjugates",
abstract = "Two new haptens were employed as antigens to elicit antibodies for acyl-transfer reactions. The haptens, both α-keto amides were designed to elicit antibodies which could twist potential substrates into a much more reactive conformation. The rationale for their design, synthesis, and immunization protocols will be discussed.Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.",
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Twisted α-keto amides as transition-state analogues for acyl-transfer reactions : Synthesis of the immunoconjugates. / Yli-Kauhaluoma, Jari; Janda, Kim (Corresponding Author).

In: Bioorganic & Medicinal Chemistry, Vol. 2, No. 6, 1994, p. 521-528.

Research output: Contribution to journalArticleScientificpeer-review

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T2 - Synthesis of the immunoconjugates

AU - Yli-Kauhaluoma, Jari

AU - Janda, Kim

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AB - Two new haptens were employed as antigens to elicit antibodies for acyl-transfer reactions. The haptens, both α-keto amides were designed to elicit antibodies which could twist potential substrates into a much more reactive conformation. The rationale for their design, synthesis, and immunization protocols will be discussed.Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.

U2 - 10.1016/0968-0896(94)80022-7

DO - 10.1016/0968-0896(94)80022-7

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EP - 528

JO - Bioorganic & Medicinal Chemistry

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