Abstract
Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 521-528 |
| Number of pages | 8 |
| Journal | Bioorganic & Medicinal Chemistry |
| Volume | 2 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1994 |
| MoE publication type | A1 Journal article-refereed |
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Twisted α-keto amides as transition-state analogues for acyl-transfer reactions : Synthesis of the immunoconjugates. / Yli-Kauhaluoma, Jari; Janda, Kim (Corresponding Author).
In: Bioorganic & Medicinal Chemistry, Vol. 2, No. 6, 1994, p. 521-528.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Twisted α-keto amides as transition-state analogues for acyl-transfer reactions
T2 - Synthesis of the immunoconjugates
AU - Yli-Kauhaluoma, Jari
AU - Janda, Kim
N1 - Project code: KET2416
PY - 1994
Y1 - 1994
N2 - Two new haptens were employed as antigens to elicit antibodies for acyl-transfer reactions. The haptens, both α-keto amides were designed to elicit antibodies which could twist potential substrates into a much more reactive conformation. The rationale for their design, synthesis, and immunization protocols will be discussed.Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.
AB - Two new haptens were employed as antigens to elicit antibodies for acyl-transfer reactions. The haptens, both α-keto amides were designed to elicit antibodies which could twist potential substrates into a much more reactive conformation. The rationale for their design, synthesis, and immunization protocols will be discussed.Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.
U2 - 10.1016/0968-0896(94)80022-7
DO - 10.1016/0968-0896(94)80022-7
M3 - Article
VL - 2
SP - 521
EP - 528
JO - Bioorganic & Medicinal Chemistry
JF - Bioorganic & Medicinal Chemistry
SN - 0968-0896
IS - 6
ER -