Twisted α-keto amides as transition-state analogues for acyl-transfer reactions: Synthesis of the immunoconjugates

Jari Yli-Kauhaluoma; Kim Janda

doi:10.1016/0968-0896(94)80022-7

Twisted α-keto amides as transition-state analogues for acyl-transfer reactions: Synthesis of the immunoconjugates

Jari Yli-Kauhaluoma, Kim Janda (Corresponding Author)

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

Two new haptens were employed as antigens to elicit antibodies for acyl-transfer reactions. The haptens, both α-keto amides were designed to elicit antibodies which could twist potential substrates into a much more reactive conformation. The rationale for their design, synthesis, and immunization protocols will be discussed.

Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.

Original language	English
Pages (from-to)	521-528
Number of pages	8
Journal	Bioorganic & Medicinal Chemistry
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/0968-0896(94)80022-7
Publication status	Published - 1994
MoE publication type	A1 Journal article-refereed

Access to Document

10.1016/0968-0896(94)80022-7

Fingerprint Dive into the research topics of 'Twisted α-keto amides as transition-state analogues for acyl-transfer reactions: Synthesis of the immunoconjugates'. Together they form a unique fingerprint.

Cite this

@article{b51f9a72c9814594974ce8a16b1cc4d7,

title = "Twisted α-keto amides as transition-state analogues for acyl-transfer reactions: Synthesis of the immunoconjugates",

abstract = "Two new haptens were employed as antigens to elicit antibodies for acyl-transfer reactions. The haptens, both α-keto amides were designed to elicit antibodies which could twist potential substrates into a much more reactive conformation. The rationale for their design, synthesis, and immunization protocols will be discussed.Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.",

author = "Jari Yli-Kauhaluoma and Kim Janda",

note = "Project code: KET2416",

year = "1994",

doi = "10.1016/0968-0896(94)80022-7",

language = "English",

volume = "2",

pages = "521--528",

journal = "Bioorganic & Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Twisted α-keto amides as transition-state analogues for acyl-transfer reactions

T2 - Synthesis of the immunoconjugates

AU - Yli-Kauhaluoma, Jari

AU - Janda, Kim

N1 - Project code: KET2416

PY - 1994

Y1 - 1994

N2 - Two new haptens were employed as antigens to elicit antibodies for acyl-transfer reactions. The haptens, both α-keto amides were designed to elicit antibodies which could twist potential substrates into a much more reactive conformation. The rationale for their design, synthesis, and immunization protocols will be discussed.Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.

AB - Two new haptens were employed as antigens to elicit antibodies for acyl-transfer reactions. The haptens, both α-keto amides were designed to elicit antibodies which could twist potential substrates into a much more reactive conformation. The rationale for their design, synthesis, and immunization protocols will be discussed.Two α-keto amides 1 and 2 were employed as antigens to elicit antibodies for acyl-transfer reactions. The rationale for their design, synthesis, and immunization protocols will be discussed.

U2 - 10.1016/0968-0896(94)80022-7

DO - 10.1016/0968-0896(94)80022-7

M3 - Article

VL - 2

SP - 521

EP - 528

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 6

ER -