Ultrahigh-performance liquid chromatography-mass spectrometry in Lipidomics

Heli Nygren, P Pöhö, Tuulikki Seppänen-Laakso, Ulla Lahtinen, M Oresic, T Hyötyläinen

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    An analytical method for the global profiling of molecular lipids in biological samples, with particular emphasis on the plasmalogen lipids, is described. The global profiling method is based on ultrahigh-performance liquid chromatography combined with quadrupole time-of-flight-mass spectrometry (UHPLC–QTOF-MS). The profiling approach is complemented by UHPLC–LTQ-Orbitrap mass spectrometry in MS n mode for de novo lipid identification.
    Original languageEnglish
    Pages (from-to)286-293
    Number of pages7
    JournalLC-GC North America
    Volume32
    Issue number4
    Publication statusPublished - 2014
    MoE publication typeA1 Journal article-refereed

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