Unanchoring integrins in focal adhesions

Johanna Ivaska (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Abstract

Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix. A detailed analysis of integrin dynamics now indicates that focal-adhesion-associated integrins constantly switch between active and immobilized, and unbound and free-diffusing states, with different fibronectin-binding integrin heterodimers showing distinct focal-adhesion dynamics.
Original languageEnglish
Pages (from-to)981-983
JournalNature Cell Biology
Volume14
Issue number10
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

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