Abstract
Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix. A detailed analysis of integrin dynamics now indicates that focal-adhesion-associated integrins constantly switch between active and immobilized, and unbound and free-diffusing states, with different fibronectin-binding integrin heterodimers showing distinct focal-adhesion dynamics.
Original language | English |
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Pages (from-to) | 981-983 |
Journal | Nature Cell Biology |
Volume | 14 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2012 |
MoE publication type | A1 Journal article-refereed |