Unanchoring integrins in focal adhesions

Johanna Ivaska

doi:10.1038/ncb2592

Unanchoring integrins in focal adhesions

Johanna Ivaska (Corresponding Author)

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

16 Citations (Scopus)

Abstract

Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix. A detailed analysis of integrin dynamics now indicates that focal-adhesion-associated integrins constantly switch between active and immobilized, and unbound and free-diffusing states, with different fibronectin-binding integrin heterodimers showing distinct focal-adhesion dynamics.

Original language	English
Pages (from-to)	981-983
Journal	Nature Cell Biology
Volume	14
Issue number	10
DOIs	https://doi.org/10.1038/ncb2592
Publication status	Published - 2012
MoE publication type	A1 Journal article-refereed

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10.1038/ncb2592

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