Unanchoring integrins in focal adhesions

Johanna Ivaska

doi:10.1038/ncb2592

Unanchoring integrins in focal adhesions

Johanna Ivaska (Corresponding Author)

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

13 Citations (Scopus)

Abstract

Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix. A detailed analysis of integrin dynamics now indicates that focal-adhesion-associated integrins constantly switch between active and immobilized, and unbound and free-diffusing states, with different fibronectin-binding integrin heterodimers showing distinct focal-adhesion dynamics.

Original language	English
Pages (from-to)	981-983
Journal	Nature Cell Biology
Volume	14
Issue number	10
DOIs	https://doi.org/10.1038/ncb2592
Publication status	Published - 2012
MoE publication type	A1 Journal article-refereed

Access to Document

10.1038/ncb2592

Fingerprint Dive into the research topics of 'Unanchoring integrins in focal adhesions'. Together they form a unique fingerprint.

Cite this

@article{d90fc232d2fd41b3a3185e280287370d,

title = "Unanchoring integrins in focal adhesions",

abstract = "Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix. A detailed analysis of integrin dynamics now indicates that focal-adhesion-associated integrins constantly switch between active and immobilized, and unbound and free-diffusing states, with different fibronectin-binding integrin heterodimers showing distinct focal-adhesion dynamics.",

author = "Johanna Ivaska",

year = "2012",

doi = "10.1038/ncb2592",

language = "English",

volume = "14",

pages = "981--983",

journal = "Nature Cell Biology",

issn = "1465-7392",

publisher = "Nature Publishing Group",

number = "10",

}

TY - JOUR

T1 - Unanchoring integrins in focal adhesions

AU - Ivaska, Johanna

PY - 2012

Y1 - 2012

N2 - Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix. A detailed analysis of integrin dynamics now indicates that focal-adhesion-associated integrins constantly switch between active and immobilized, and unbound and free-diffusing states, with different fibronectin-binding integrin heterodimers showing distinct focal-adhesion dynamics.

AB - Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix. A detailed analysis of integrin dynamics now indicates that focal-adhesion-associated integrins constantly switch between active and immobilized, and unbound and free-diffusing states, with different fibronectin-binding integrin heterodimers showing distinct focal-adhesion dynamics.

U2 - 10.1038/ncb2592

DO - 10.1038/ncb2592

M3 - Article

VL - 14

SP - 981

EP - 983

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 10

ER -