Use of optical skin phantoms for preclinical evaluation of laser efficiency for skin lesion therapy

Maciej S. Wróbel, Malgorzata Jȩdrzejewska-Szczerska, Stanislaw Galla, Leszek Piechowski, Miroslaw Sawczak, Alexey P. Popov, Alexander V. Bykov, Valery V. Tuchin, Adam Cenian

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24 Citations (Scopus)

Abstract

Skin lesions are commonly treated using laser heating. However, the introduction of new devices into clinical practice requires evaluation of their performance. This study presents the application of optical phantoms for assessment of a newly developed 975-nm pulsed diode laser system for dermatological purposes. Such phantoms closely mimic the absorption and scattering of real human skin (although not precisely in relation to thermal conductivity and capacitance); thus, they can be used as substitutes for human skin for approximate evaluation of laser heating efficiency in an almost real environment. Thermographic imaging was applied to measure the spatial and temporal temperature distributions on the surface of laser-irradiated phantoms. The study yielded results of heating with regard to phantom thickness and absorption, as well as laser settings. The methodology developed can be used in practice for preclinical evaluations of laser treatment for dermatology.

Original languageEnglish
Article number085003
JournalJournal of Biomedical Optics
Volume20
Issue number8
DOIs
Publication statusPublished - 1 Aug 2015
MoE publication typeA1 Journal article-refereed

Keywords

  • lasers in medicine
  • optical properties
  • thermography
  • tissue-mimicking phantoms
  • tissues

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    Wróbel, M. S., Jȩdrzejewska-Szczerska, M., Galla, S., Piechowski, L., Sawczak, M., Popov, A. P., Bykov, A. V., Tuchin, V. V., & Cenian, A. (2015). Use of optical skin phantoms for preclinical evaluation of laser efficiency for skin lesion therapy. Journal of Biomedical Optics, 20(8), [085003]. https://doi.org/10.1117/1.JBO.20.8.085003