Vimentin

Central hub in EMT induction?

Johanna Ivaska (Corresponding Author)

Research output: Contribution to journalOther journal contributionScientific

88 Citations (Scopus)

Abstract

Epithelial- to-mesenchymal transition (EMT) is a critical event in the induction of cell motility and increased survival both under physiological situations like wound healing and during development as well as in malignant cells undergoing invasion and metastasis. Vimentin is an intermediate filament protein which is characteristically upregulated in cells undergoing EMT. For decades vimentin has been considered as a marker for EMT but its functional contribution to the process has remained unclear. Our data demonstrate that vimentin contributes to EMT via upregulating the gene expression of several EMT-linked genes. Especially, we find that vimentin regulates EMT associated induced migration via upregulation of the expression of receptor tyrosine kinase Axl. In addition to our data, several other exciting recent studies support the notion that vimentin in fact functions as a positive regulator of EMT and upregulation of vimentin appears to be a prerequisite for EMT induction.
Original languageEnglish
Pages (from-to)51-53
Number of pages3
JournalSmall GTPases
Volume2
Issue number1
DOIs
Publication statusPublished - 2011
MoE publication typeB1 Article in a scientific magazine

Fingerprint

Epithelial-Mesenchymal Transition
Vimentin
Intermediate Filament Proteins
Up-Regulation
Receptor Protein-Tyrosine Kinases
Gene expression
Genes
Cells
Wound Healing
Cell Movement
Neoplasm Metastasis
Gene Expression

Keywords

  • Ras
  • EMT
  • vimentin
  • Akt
  • polarity
  • migration
  • Axl

Cite this

Ivaska, Johanna. / Vimentin : Central hub in EMT induction?. In: Small GTPases. 2011 ; Vol. 2, No. 1. pp. 51-53.
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Vimentin : Central hub in EMT induction? / Ivaska, Johanna (Corresponding Author).

In: Small GTPases, Vol. 2, No. 1, 2011, p. 51-53.

Research output: Contribution to journalOther journal contributionScientific

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T2 - Central hub in EMT induction?

AU - Ivaska, Johanna

PY - 2011

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AB - Epithelial- to-mesenchymal transition (EMT) is a critical event in the induction of cell motility and increased survival both under physiological situations like wound healing and during development as well as in malignant cells undergoing invasion and metastasis. Vimentin is an intermediate filament protein which is characteristically upregulated in cells undergoing EMT. For decades vimentin has been considered as a marker for EMT but its functional contribution to the process has remained unclear. Our data demonstrate that vimentin contributes to EMT via upregulating the gene expression of several EMT-linked genes. Especially, we find that vimentin regulates EMT associated induced migration via upregulation of the expression of receptor tyrosine kinase Axl. In addition to our data, several other exciting recent studies support the notion that vimentin in fact functions as a positive regulator of EMT and upregulation of vimentin appears to be a prerequisite for EMT induction.

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