Abstract
Background Atrophy of the medial temporal lobe (MTL) is
the main structural magnetic resonance imaging (MRI)
finding in the brain of patients with Alzheimer's disease
(AD). However, evaluating the degree of atrophy is still
demanding.
Purpose The visual rating method (VRM) was compared with
multi-template tensor-based morphometry (TBM), in terms
of its efficacy in diagnosing of mild cognitive
impairment (MCI) and AD.
Material and Methods Forty-seven patients with MCI, 80
patients with AD and 84 controls were studied.
Results TBM seems to be more sensitive than VRM at the
early stage of dementia in the areas of MTL and
ventricles. The methods were equally good in
distinguishing controls and the MCI group from the AD
group. At the frontal areas TBM was better than VRM in
all comparisons.
Conclusion A user-friendly VRM is still useful for the
clinical evaluation of MCI patients, but multi-template
TBM is more sensitive for diagnosing the early stages of
dementia. However, TBM is currently too demanding to use
for daily clinical work.
| Original language | English |
|---|---|
| Pages (from-to) | 348-355 |
| Journal | Acta Radiologica |
| Volume | 57 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 |
| MoE publication type | A1 Journal article-refereed |
Keywords
- visual rating
- tensor-based morphometry
- Alzheimer's disease
- mild cognitive impairment
- magnetic resonance imaging (MRI)