Visual rating method and tensor-based morphometry in the diagnosis of mild cognitive impairment and Alzheimer's disease: A comparative magnetic resonance imaging study

Terhi Tuokkola, Juha Koikkalainen, Riitta Parkkola, Mira Karrasch, Jyrki Lötjönen, Juha Rinne

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

Background Atrophy of the medial temporal lobe (MTL) is the main structural magnetic resonance imaging (MRI) finding in the brain of patients with Alzheimer's disease (AD). However, evaluating the degree of atrophy is still demanding. Purpose The visual rating method (VRM) was compared with multi-template tensor-based morphometry (TBM), in terms of its efficacy in diagnosing of mild cognitive impairment (MCI) and AD. Material and Methods Forty-seven patients with MCI, 80 patients with AD and 84 controls were studied. Results TBM seems to be more sensitive than VRM at the early stage of dementia in the areas of MTL and ventricles. The methods were equally good in distinguishing controls and the MCI group from the AD group. At the frontal areas TBM was better than VRM in all comparisons. Conclusion A user-friendly VRM is still useful for the clinical evaluation of MCI patients, but multi-template TBM is more sensitive for diagnosing the early stages of dementia. However, TBM is currently too demanding to use for daily clinical work.
Original languageEnglish
Pages (from-to)348-355
JournalActa Radiologica
Volume57
Issue number3
DOIs
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed

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Alzheimer Disease
Magnetic Resonance Imaging
Temporal Lobe
Atrophy
Dementia
Cognitive Dysfunction
Brain

Keywords

  • visual rating
  • tensor-based morphometry
  • Alzheimer's disease
  • mild cognitive impairment
  • magnetic resonance imaging (MRI)

Cite this

Tuokkola, Terhi ; Koikkalainen, Juha ; Parkkola, Riitta ; Karrasch, Mira ; Lötjönen, Jyrki ; Rinne, Juha. / Visual rating method and tensor-based morphometry in the diagnosis of mild cognitive impairment and Alzheimer's disease : A comparative magnetic resonance imaging study. In: Acta Radiologica. 2015 ; Vol. 57, No. 3. pp. 348-355.
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abstract = "Background Atrophy of the medial temporal lobe (MTL) is the main structural magnetic resonance imaging (MRI) finding in the brain of patients with Alzheimer's disease (AD). However, evaluating the degree of atrophy is still demanding. Purpose The visual rating method (VRM) was compared with multi-template tensor-based morphometry (TBM), in terms of its efficacy in diagnosing of mild cognitive impairment (MCI) and AD. Material and Methods Forty-seven patients with MCI, 80 patients with AD and 84 controls were studied. Results TBM seems to be more sensitive than VRM at the early stage of dementia in the areas of MTL and ventricles. The methods were equally good in distinguishing controls and the MCI group from the AD group. At the frontal areas TBM was better than VRM in all comparisons. Conclusion A user-friendly VRM is still useful for the clinical evaluation of MCI patients, but multi-template TBM is more sensitive for diagnosing the early stages of dementia. However, TBM is currently too demanding to use for daily clinical work.",
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Visual rating method and tensor-based morphometry in the diagnosis of mild cognitive impairment and Alzheimer's disease : A comparative magnetic resonance imaging study. / Tuokkola, Terhi; Koikkalainen, Juha; Parkkola, Riitta; Karrasch, Mira; Lötjönen, Jyrki; Rinne, Juha.

In: Acta Radiologica, Vol. 57, No. 3, 2015, p. 348-355.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Visual rating method and tensor-based morphometry in the diagnosis of mild cognitive impairment and Alzheimer's disease

T2 - A comparative magnetic resonance imaging study

AU - Tuokkola, Terhi

AU - Koikkalainen, Juha

AU - Parkkola, Riitta

AU - Karrasch, Mira

AU - Lötjönen, Jyrki

AU - Rinne, Juha

N1 - Project code: 100745

PY - 2015

Y1 - 2015

N2 - Background Atrophy of the medial temporal lobe (MTL) is the main structural magnetic resonance imaging (MRI) finding in the brain of patients with Alzheimer's disease (AD). However, evaluating the degree of atrophy is still demanding. Purpose The visual rating method (VRM) was compared with multi-template tensor-based morphometry (TBM), in terms of its efficacy in diagnosing of mild cognitive impairment (MCI) and AD. Material and Methods Forty-seven patients with MCI, 80 patients with AD and 84 controls were studied. Results TBM seems to be more sensitive than VRM at the early stage of dementia in the areas of MTL and ventricles. The methods were equally good in distinguishing controls and the MCI group from the AD group. At the frontal areas TBM was better than VRM in all comparisons. Conclusion A user-friendly VRM is still useful for the clinical evaluation of MCI patients, but multi-template TBM is more sensitive for diagnosing the early stages of dementia. However, TBM is currently too demanding to use for daily clinical work.

AB - Background Atrophy of the medial temporal lobe (MTL) is the main structural magnetic resonance imaging (MRI) finding in the brain of patients with Alzheimer's disease (AD). However, evaluating the degree of atrophy is still demanding. Purpose The visual rating method (VRM) was compared with multi-template tensor-based morphometry (TBM), in terms of its efficacy in diagnosing of mild cognitive impairment (MCI) and AD. Material and Methods Forty-seven patients with MCI, 80 patients with AD and 84 controls were studied. Results TBM seems to be more sensitive than VRM at the early stage of dementia in the areas of MTL and ventricles. The methods were equally good in distinguishing controls and the MCI group from the AD group. At the frontal areas TBM was better than VRM in all comparisons. Conclusion A user-friendly VRM is still useful for the clinical evaluation of MCI patients, but multi-template TBM is more sensitive for diagnosing the early stages of dementia. However, TBM is currently too demanding to use for daily clinical work.

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