Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome

A randomized study

O.K. Magnusdottir (Corresponding Author), R. Landberg, I. Gunnarsdottir, L. Cloetens, B. Åkesson, F. Rosqvist, U. Schwab, K.-H. Herzig, J. Hukkanen, M.J. Savolainen, L. Brader, K. Hermansen, Marjukka Kolehmainen, Kaisa Poutanen, M. Uusitupa, U. Risérus, I. Thorsdottir

Research output: Contribution to journalArticleScientificpeer-review

18 Citations (Scopus)

Abstract

Background and Aim: Few studies have explored the possible plasma cholesterol lowering effects of rye consumption. The aim of this secondary analysis in the SYSDIET study was to investigate the association between plasma alkylresorcinols (AR), a biomarker for whole grain wheat and rye intake, and blood lipid concentrations in a population with metabolic syndrome. Furthermore, we analyzed the associations between the AR C17:0/C21:0 ratio, a suggested marker of the relative intake of whole grain/bran rye, and blood lipid concentrations. Methods: Participants were 30-65 years of age, with body mass index (BMI) 27-40 kg/m2 and had metabolic syndrome. Individuals were recruited through six centers in the Nordic countries and randomized either to a healthy Nordic diet (ND, n = 93), rich in whole grain rye and wheat, as well as berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products, or a control diet (n=65) for 18/24 weeks. Associations between total plasma AR concentration and C17:0/C21:0 homologue ratio and blood lipids were investigated in pooled (ND + control group) regression analyses at 18/24 weeks adjusted for baseline value for the dependent variable, age, BMI and statin use. Results: When adjusted for confounders, total plasma AR at 18/24 weeks was not significantly associated with blood lipids but the AR ratio C17:0/C21:0 was inversely associated with LDL cholesterol concentrations (B (95% CI): 20.41 (20.80 to 20.02)), log LDL/HDL cholesterol ratio (20.20 (20.37 to 20.03)), log non-HDL cholesterol (20.20 (20.37 to 20.03)), log apolipoprotein B (20.12 (20.24 to 0.00)) and log triglyceride concentrations (20.35 (20.59 to 20.12)). Discussion: Increased proportion of whole grain rye, reflected by a biomarker, in the diet is associated with favorable blood lipid outcomes, a relationship that should be further investigated.
Original languageEnglish
Article numbere110827
JournalPLoS ONE
Volume9
Issue number10
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

Fingerprint

alkylresorcinols
whole grain foods
metabolic syndrome
Biomarkers
blood lipids
rye
biomarkers
Blood
Lipids
Nutrition
Plasmas
low density lipoprotein cholesterol
LDL Cholesterol
Triticum
body mass index
Fruit
Body Mass Index
low fat dairy products
rye bran
Cholesterol

Keywords

  • biomarkers
  • blood plasma
  • cholesterol
  • diet
  • diabetes
  • rye
  • wheat

Cite this

Magnusdottir, O. K., Landberg, R., Gunnarsdottir, I., Cloetens, L., Åkesson, B., Rosqvist, F., ... Thorsdottir, I. (2014). Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome: A randomized study. PLoS ONE, 9(10), [e110827]. https://doi.org/10.1371/journal.pone.0110827
Magnusdottir, O.K. ; Landberg, R. ; Gunnarsdottir, I. ; Cloetens, L. ; Åkesson, B. ; Rosqvist, F. ; Schwab, U. ; Herzig, K.-H. ; Hukkanen, J. ; Savolainen, M.J. ; Brader, L. ; Hermansen, K. ; Kolehmainen, Marjukka ; Poutanen, Kaisa ; Uusitupa, M. ; Risérus, U. ; Thorsdottir, I. / Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome : A randomized study. In: PLoS ONE. 2014 ; Vol. 9, No. 10.
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title = "Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome: A randomized study",
abstract = "Background and Aim: Few studies have explored the possible plasma cholesterol lowering effects of rye consumption. The aim of this secondary analysis in the SYSDIET study was to investigate the association between plasma alkylresorcinols (AR), a biomarker for whole grain wheat and rye intake, and blood lipid concentrations in a population with metabolic syndrome. Furthermore, we analyzed the associations between the AR C17:0/C21:0 ratio, a suggested marker of the relative intake of whole grain/bran rye, and blood lipid concentrations. Methods: Participants were 30-65 years of age, with body mass index (BMI) 27-40 kg/m2 and had metabolic syndrome. Individuals were recruited through six centers in the Nordic countries and randomized either to a healthy Nordic diet (ND, n = 93), rich in whole grain rye and wheat, as well as berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products, or a control diet (n=65) for 18/24 weeks. Associations between total plasma AR concentration and C17:0/C21:0 homologue ratio and blood lipids were investigated in pooled (ND + control group) regression analyses at 18/24 weeks adjusted for baseline value for the dependent variable, age, BMI and statin use. Results: When adjusted for confounders, total plasma AR at 18/24 weeks was not significantly associated with blood lipids but the AR ratio C17:0/C21:0 was inversely associated with LDL cholesterol concentrations (B (95{\%} CI): 20.41 (20.80 to 20.02)), log LDL/HDL cholesterol ratio (20.20 (20.37 to 20.03)), log non-HDL cholesterol (20.20 (20.37 to 20.03)), log apolipoprotein B (20.12 (20.24 to 0.00)) and log triglyceride concentrations (20.35 (20.59 to 20.12)). Discussion: Increased proportion of whole grain rye, reflected by a biomarker, in the diet is associated with favorable blood lipid outcomes, a relationship that should be further investigated.",
keywords = "biomarkers, blood plasma, cholesterol, diet, diabetes, rye, wheat",
author = "O.K. Magnusdottir and R. Landberg and I. Gunnarsdottir and L. Cloetens and B. {\AA}kesson and F. Rosqvist and U. Schwab and K.-H. Herzig and J. Hukkanen and M.J. Savolainen and L. Brader and K. Hermansen and Marjukka Kolehmainen and Kaisa Poutanen and M. Uusitupa and U. Ris{\'e}rus and I. Thorsdottir",
year = "2014",
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language = "English",
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journal = "PLoS ONE",
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Magnusdottir, OK, Landberg, R, Gunnarsdottir, I, Cloetens, L, Åkesson, B, Rosqvist, F, Schwab, U, Herzig, K-H, Hukkanen, J, Savolainen, MJ, Brader, L, Hermansen, K, Kolehmainen, M, Poutanen, K, Uusitupa, M, Risérus, U & Thorsdottir, I 2014, 'Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome: A randomized study', PLoS ONE, vol. 9, no. 10, e110827. https://doi.org/10.1371/journal.pone.0110827

Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome : A randomized study. / Magnusdottir, O.K. (Corresponding Author); Landberg, R.; Gunnarsdottir, I.; Cloetens, L.; Åkesson, B.; Rosqvist, F.; Schwab, U.; Herzig, K.-H.; Hukkanen, J.; Savolainen, M.J.; Brader, L.; Hermansen, K.; Kolehmainen, Marjukka; Poutanen, Kaisa; Uusitupa, M.; Risérus, U.; Thorsdottir, I.

In: PLoS ONE, Vol. 9, No. 10, e110827, 2014.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome

T2 - A randomized study

AU - Magnusdottir, O.K.

AU - Landberg, R.

AU - Gunnarsdottir, I.

AU - Cloetens, L.

AU - Åkesson, B.

AU - Rosqvist, F.

AU - Schwab, U.

AU - Herzig, K.-H.

AU - Hukkanen, J.

AU - Savolainen, M.J.

AU - Brader, L.

AU - Hermansen, K.

AU - Kolehmainen, Marjukka

AU - Poutanen, Kaisa

AU - Uusitupa, M.

AU - Risérus, U.

AU - Thorsdottir, I.

PY - 2014

Y1 - 2014

N2 - Background and Aim: Few studies have explored the possible plasma cholesterol lowering effects of rye consumption. The aim of this secondary analysis in the SYSDIET study was to investigate the association between plasma alkylresorcinols (AR), a biomarker for whole grain wheat and rye intake, and blood lipid concentrations in a population with metabolic syndrome. Furthermore, we analyzed the associations between the AR C17:0/C21:0 ratio, a suggested marker of the relative intake of whole grain/bran rye, and blood lipid concentrations. Methods: Participants were 30-65 years of age, with body mass index (BMI) 27-40 kg/m2 and had metabolic syndrome. Individuals were recruited through six centers in the Nordic countries and randomized either to a healthy Nordic diet (ND, n = 93), rich in whole grain rye and wheat, as well as berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products, or a control diet (n=65) for 18/24 weeks. Associations between total plasma AR concentration and C17:0/C21:0 homologue ratio and blood lipids were investigated in pooled (ND + control group) regression analyses at 18/24 weeks adjusted for baseline value for the dependent variable, age, BMI and statin use. Results: When adjusted for confounders, total plasma AR at 18/24 weeks was not significantly associated with blood lipids but the AR ratio C17:0/C21:0 was inversely associated with LDL cholesterol concentrations (B (95% CI): 20.41 (20.80 to 20.02)), log LDL/HDL cholesterol ratio (20.20 (20.37 to 20.03)), log non-HDL cholesterol (20.20 (20.37 to 20.03)), log apolipoprotein B (20.12 (20.24 to 0.00)) and log triglyceride concentrations (20.35 (20.59 to 20.12)). Discussion: Increased proportion of whole grain rye, reflected by a biomarker, in the diet is associated with favorable blood lipid outcomes, a relationship that should be further investigated.

AB - Background and Aim: Few studies have explored the possible plasma cholesterol lowering effects of rye consumption. The aim of this secondary analysis in the SYSDIET study was to investigate the association between plasma alkylresorcinols (AR), a biomarker for whole grain wheat and rye intake, and blood lipid concentrations in a population with metabolic syndrome. Furthermore, we analyzed the associations between the AR C17:0/C21:0 ratio, a suggested marker of the relative intake of whole grain/bran rye, and blood lipid concentrations. Methods: Participants were 30-65 years of age, with body mass index (BMI) 27-40 kg/m2 and had metabolic syndrome. Individuals were recruited through six centers in the Nordic countries and randomized either to a healthy Nordic diet (ND, n = 93), rich in whole grain rye and wheat, as well as berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products, or a control diet (n=65) for 18/24 weeks. Associations between total plasma AR concentration and C17:0/C21:0 homologue ratio and blood lipids were investigated in pooled (ND + control group) regression analyses at 18/24 weeks adjusted for baseline value for the dependent variable, age, BMI and statin use. Results: When adjusted for confounders, total plasma AR at 18/24 weeks was not significantly associated with blood lipids but the AR ratio C17:0/C21:0 was inversely associated with LDL cholesterol concentrations (B (95% CI): 20.41 (20.80 to 20.02)), log LDL/HDL cholesterol ratio (20.20 (20.37 to 20.03)), log non-HDL cholesterol (20.20 (20.37 to 20.03)), log apolipoprotein B (20.12 (20.24 to 0.00)) and log triglyceride concentrations (20.35 (20.59 to 20.12)). Discussion: Increased proportion of whole grain rye, reflected by a biomarker, in the diet is associated with favorable blood lipid outcomes, a relationship that should be further investigated.

KW - biomarkers

KW - blood plasma

KW - cholesterol

KW - diet

KW - diabetes

KW - rye

KW - wheat

U2 - 10.1371/journal.pone.0110827

DO - 10.1371/journal.pone.0110827

M3 - Article

VL - 9

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 10

M1 - e110827

ER -